Catalytic asymmetric formal total syntheses of (+)- and (−)-cycloclavine
| Autor: | Santanu Ghosh, Alakesh Bisai, Saikat Chaudhuri, Subhajit Bhunia |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cycloclavine
010405 organic chemistry Chemistry Stereochemistry Metals and Alloys Clavine Alkaloids Total synthesis General Chemistry 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Stereocenter Materials Chemistry Ceramics and Composites Vicinal |
| Zdroj: | Chemical Communications. 54:940-943 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | We report an expeditious catalytic asymmetric approach to clavine alkaloids via a key Heck cyclization. This reaction sets the formation of vicinal stereocenters with excellent diastereoselectivity. Utilizing the aforementioned strategy, the formal total synthesis of cycloclavine (1) has been achieved via another key late-stage ester-aminolysis of 6. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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