Perioperative factors associated with persistent opioid use after extensive abdominal surgery in children and adolescents: A retrospective cohort study

Autor:	Uduak Ursula Williams, Andrea Hayes-Jordan, Juan P. Cata, Acsa M. Zavala, Ravish Kapoor, Antoinette Van Meter, Elizabeth Rebello, January Tsai, Pascal Owusu-Agyemang, Lei Feng
Rok vydání:	2018
Předmět:	Male medicine.medical_specialty Adolescent Logistic regression Drug Administration Schedule Time Odds Cohort Studies 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology Internal medicine Abdomen Prevalence medicine Humans Child Perioperative Period Retrospective Studies Pain Postoperative business.industry Retrospective cohort study Cytoreduction Surgical Procedures Hyperthermia Induced Perioperative Odds ratio Confidence interval Analgesics Opioid Anesthesiology and Pain Medicine Abdominal Neoplasms Pediatrics Perinatology and Child Health Female Hyperthermic intraperitoneal chemotherapy Chronic Pain business 030217 neurology & neurosurgery Abdominal surgery
Zdroj:	Pediatric Anesthesia. 28:625-631
ISSN:	1155-5645
DOI:	10.1111/pan.13386
Popis:	BACKGROUND In adults, preoperative opioid use and higher perioperative opioid consumption have been associated with higher odds of persistent opioid use after surgery. There are limited data on the prevalence and factors associated with persistent opioid use after major oncologic surgery in children. AIMS In this study, we sought to determine the prevalence and factors associated with the development of persistent opioid use in a group of children and adolescents who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy. METHODS A retrospective study of patients ≤19 years of age was performed. Univariable logistic regression was used to assess factors associated with a postdischarge persistent opioid use of up to 6 months. RESULTS Eighty-six children were identified. The median age was 12 years, and 43% were female. The proportion of patients with persistent opioid use over the immediate 3, 6, 12 and 24 postdischarge months was 54/77 (70%), 18/51 (35%), 13/45 (29%), and 3/24 (13%), respectively. The daily average in-patient pain scores were higher in the group of children who subsequently developed persistent opioid use of up to 6 months (estimated difference 0.5, 95% confidence interval [CI]: 0.3, 0.8, P
Databáze:	OpenAIRE
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