Behavioral and Accumbal Responses During an Affective Go/No-Go Task Predict Adherence to Injectable Naltrexone Treatment in Opioid Use Disorder

Autor: Jesse J. Suh, Victoria P. Fairchild, Anna Rose Childress, An-Li Wang, Daniel Langleben, Kanchana Jagannathan, Kevin G. Lynch, Zhenhao Shi
Rok vydání: 2019
Předmět:
Adult
Male
Adolescent
nucleus accumbens
Narcotic Antagonists
Treatment outcome
Relapse prevention
Injections
Intramuscular
Naltrexone
Medication Adherence
Task (project management)
Young Adult
extended-release naltrexone
03 medical and health sciences
0302 clinical medicine
Outcome variable
Predictive Value of Tests
medicine
Humans
Pharmacology (medical)
adherence
030304 developmental biology
Pharmacology
0303 health sciences
medicine.diagnostic_test
business.industry
Brief Report
opioid use disorder
Opioid use disorder
Opioid-Related Disorders
medicine.disease
Magnetic Resonance Imaging
3. Good health
Editor's Choice
Psychiatry and Mental health
Treatment Outcome
Delayed-Action Preparations
Go/no go
Female
errors of commission
Functional magnetic resonance imaging
business
Photic Stimulation
Psychomotor Performance
030217 neurology & neurosurgery
medicine.drug
Clinical psychology
Zdroj: International Journal of Neuropsychopharmacology
ISSN: 1469-5111
1461-1457
DOI: 10.1093/ijnp/pyz002
Popis: Adherence is a major factor in the effectiveness of the injectable extended-release naltrexone as a relapse prevention treatment in opioid use disorder. We examined the value of a variant of the Go/No-go paradigm in predicting extended-release naltrexone adherence in 27 detoxified opioid use disorder patients who were offered up to 3 monthly extended-release naltrexone injections. Before extended-release naltrexone, participants performed a Go/No-go task that comprised positively valenced Go trials and negatively valenced No-go trials during a functional magnetic resonance imaging scan. Errors of commission and neural responses to the No-go vs Go trials were independent variables. Adherence, operationalized as the completion of all 3 extended-release naltrexone injections, was the outcome variable. Fewer errors of commission and greater left accumbal response during the No-go vs Go trials predicted better adherence. These findings support the clinical potential of the behavioral and neurophysiological correlates of response inhibition in the prediction of extended-release naltrexone treatment outcomes in opioid use disorder.
Databáze: OpenAIRE
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