Neuroregenerative strategies in the brain: emerging significance of bone morphogenetic protein 7 (BMP7)
| Autor: | Sandhya Gangaraju, Bogdan Zurakowski, David ChittyD. Chitty, Marianna Sikorska, Roger Tremblay, Mahmud Bani-Yaghoub, Munyao Nzau, Abdellah Ajji |
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| Rok vydání: | 2008 |
| Předmět: |
Canada
potential Cell Survival Cell Transplantation Bone Morphogenetic Protein 7 Neurogenesis Biochemistry Neuroprotection Brain repair brain injuries Neurotrophic factors Cognitive problems medicine Animals Humans In patient Molecular Biology Stroke disease therapy model Tissue Engineering business.industry Brain Cell Differentiation Cell Biology medicine.disease Neuroregeneration cytokines drug therapy Nerve Regeneration Bone morphogenetic protein 7 Neuroprotective Agents therapeutic use physiology role pathology program protein business metabolism Neuroscience |
| Zdroj: | Biochemistry and cell biology = Biochimie et biologie cellulaire. 86(5) |
| ISSN: | 0829-8211 |
| Popis: | Every year thousands of people suffer from brain injuries and stroke, and develop motor, sensory, and cognitive problems as a result of neuronal loss in the brain. Unfortunately, the damaged brain has a limited ability to enact repair and current modes of treatment are not sufficient to offset the damage. An extensive list of growth factors, neurotrophic factors, cytokines, and drugs has been explored as potential therapies. However, only a limited number of them may actually have the potential to effectively offset the brain injury or stroke-related problems. One of the treatments considered for future brain repair is bone morphogenetic protein 7 (BMP7), a factor currently used in patients to treat non-neurological diseases. The clinical application of BMP7 is based on its neuroprotective role in stroke animal models. This paper reviews the current approaches considered for brain repair and discusses the novel convergent strategies by which BMP7 potentially can induce neuroregeneration. |
| Databáze: | OpenAIRE |
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