The accuracy of cystatin C and commonly used creatinine-based methods for detecting moderate and mild chronic kidney disease in diabetes
| Autor: | Erosha Premaratne, Richard J MacIsaac, Sujiva Ratnaike, Merlin C. Thomas, George Jerums, Con Tsalamandris, David A. Power, Margaret A Jenkins, A Poon, Sianna Panagiotopoulos, Thomas J. Smith |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Urology Renal function urologic and male genital diseases Kidney Function Tests Sensitivity and Specificity Severity of Illness Index Diabetic nephropathy chemistry.chemical_compound Endocrinology Predictive Value of Tests Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Humans Diabetic Nephropathies reproductive and urinary physiology Aged Aged 80 and over Creatinine Proteinuria biology business.industry Middle Aged medicine.disease Cystatins female genital diseases and pregnancy complications Cross-Sectional Studies chemistry Cystatin C biology.protein Microalbuminuria Female medicine.symptom business Kidney disease Glomerular Filtration Rate |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 24(4) |
| ISSN: | 0742-3071 |
| Popis: | Background The accuracy of measuring serum cystatin C levels for detecting various stages of chronic kidney disease (CKD) in diabetes is still unclear. Methods In a cross-sectional study of 251 subjects, a reference glomerular filtration rate (GFR) was measured using 99cTc-DTPA plasma clearance (iGFR). Multivariate analysis was used to identify independent clinical and biochemical associations with serum cystatin C and iGFR levels. The diagnostic accuracy of cystatin C and commonly used creatinine-based methods of measuring renal function (serum creatinine, the MDRD four-variable and Cockcroft–Gault formulae) for detecting mild and moderate CKD was also compared. Results In the entire study population the same five variables, age, urinary albumin excretion rates, haemoglobin, history of macrovascular disease and triglyceride levels were independently associated with both cystatin C and iGFR levels. A serum cystatin C level cut-off > 82.1 nmol/l (1.10 mg/l) had the best test characteristics as a screening tool for detecting moderate CKD ( |
| Databáze: | OpenAIRE |
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