Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats
| Autor: | Jerome Demmer, P. Lawlor, Mike Dragunow, J.D. Leah, Warren P. Tate, S.E. Mason, Wickliffe C. Abraham |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Transcription Genetic Hippocampus Hippocampal formation Biology Neurotransmission Rats Sprague-Dawley Cellular and Molecular Neuroscience Genes jun Internal medicine medicine LTP induction Animals Molecular Biology Neuronal Plasticity Dentate gyrus Genes fos Long-term potentiation Perforant path Rats medicine.anatomical_structure Endocrinology Gene Expression Regulation nervous system Neuroscience Immediate early gene |
| Zdroj: | Molecular Brain Research. 17:279-286 |
| ISSN: | 0169-328X |
| DOI: | 10.1016/0169-328x(93)90012-e |
| Popis: | The pattern of expression of fos and jun family immediate early genes following the induction of long-term potentiation (LTP) was investigated in the dentate gyrus of awake rats. Rapid, transient increases in the levels of c-jun and jun-B mRNA and protein, and in the levels of Fos-related proteins (FRAs), occurred in the dentate gyrus after LTP-inducing tetanization of the perforant path. A delayed, and more prolonged induction occurred for jun-D mRNA and protein. The induction of c-Jun, Jun-B, Jun-D and Fos-related proteins was prevented by administration of an N-methyl-D-aspartate receptor antagonist, which also blocked LTP induction, and by pentobarbital, which reduced but did not block LTP. These findings show that differential expression of fos and jun gene family members occurs in a distinct pattern following LTP in awake rats. The responsive genes may participate in the biochemical cascade leading to the long-term stabilization of synaptic modifications. |
| Databáze: | OpenAIRE |
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