Deletion (8)(q22) as the only chromosomal abnormality in a patient with RAEB-t with progression to acute myelocytic leukemia
| Autor: | Barbara Bong, A. S. P. M. Breed, Lutgarde Govaerts, Bauke de Jong, Simon Daenen |
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| Rok vydání: | 1988 |
| Předmět: |
Cancer Research
medicine.medical_specialty Myeloid Chromosomal translocation Biology Malignant transformation hemic and lymphatic diseases Genetics medicine Humans Molecular Biology Aged Aged 80 and over Anemia Refractory with Excess of Blasts Breakpoint Cytogenetics Karyotype medicine.disease Virology Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Karyotyping Cancer research Female Bone marrow Chromosome Deletion Chromosomes Human Pair 8 |
| Zdroj: | Cancer genetics and cytogenetics. 30(2) |
| ISSN: | 0165-4608 |
| Popis: | Cytogenetic investigation of the bone marrow cells of an 88-year-old woman with refractory anemia with an excess of blasts in transformation with progression to acute myelocytic leukemia (AML), FAB classification M4, revealed a deleted chromosome #8 with the breakpoint at band q22 as the sole abnormality. This breakpoint is the same as that in t(8;21)(q22;q22), mostly found in patients with AML. This finding is discussed in relation to the possible oncogenesis of AML, which in this case may mean that the deletion of chromosome #8 at band 8q22 and the resultant loss of genetic material with possible antioncogenic activity is the critical event leading to malignant transformation in AML and not the translocation of the end of 21q next to 8q. |
| Databáze: | OpenAIRE |
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