Bronchoalveolar cellularity and interleukin-8 levels in measles bronchiolitis obliterans
| Autor: | Young Yull Koh, Jung Yeon Kim, Ji Yeon Koh, Da Eun Jung, Young Yoo, Chang Keun Kim |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Pathology medicine.medical_specialty CD3 Complex Neutrophils Biopsy CD8 Antigens T-Lymphocytes Bronchiolitis obliterans Cell Count Critical Care and Intensive Care Medicine Measles Measles virus Bronchoscopy medicine Humans Interleukin 8 Bronchiolitis Obliterans Lung biology business.industry Respiratory disease Interleukin-8 Interleukin Infant biology.organism_classification medicine.disease Pneumonia medicine.anatomical_structure Case-Control Studies Child Preschool Immunology Female Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed Bronchoalveolar Lavage Fluid |
| Zdroj: | Chest. 131(5) |
| ISSN: | 0012-3692 |
| Popis: | Measles virus infection may progress to a chronic obstructive process including bronchiolitis obliterans (BO). This study investigates pulmonary cellular profiles and interleukin (IL)-8 levels in patients with BO following the measles.BAL fluid was obtained from 12 children with BO who had a history of measles pneumonia during an outbreak in 2000 and 2001. BAL cell counts and differentials were compared to control patients as well as BAL IL-8 levels, which were measured by enzyme-linked immunosorbent assay. Immunohistochemical staining of BAL cells and three open-lung biopsy specimens were also analyzed for T-cell surface markers CD3, CD4, and CD8.BAL cellular profiles were characterized by a significantly increased percentage of neutrophils in the measles BO group (median, 16.0%) compared to the control group (2.3%) [p0.01]. BAL IL-8 levels were also markedly increased in the measles BO group (mean +/- SD, 418.6 +/- 286.0 pg/mL) compared to the control group (92.8 +/- 126.7 pg/mL) [p0.01]. BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). The lymphocyte subsets were characterized by a significantly increased number of CD8+ cells, resulting in a decreased CD4/CD8 ratio in the BAL and the biopsy specimens.These results suggest that pulmonary neutrophils and IL-8, along with CD8+ T lymphocytes may play an important role in the pathogenesis of BO after measles virus infection. |
| Databáze: | OpenAIRE |
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