Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions
| Autor: | Alexandra Münster, Susanne Sommer, Diana Kúkeľová, Hannes Sigrist, Eliza Koros, Serena Deiana, Klaus Klinder, Tamara Baader-Pagler, Svenja Mayer-Wrangowski, Boris Ferger, Tom Bretschneider, Christopher R. Pryce, Wolfgang Hauber, Moritz von Heimendahl |
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| Přispěvatelé: | University of Zurich, von Heimendahl, Moritz |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Motivation Dopamine 2804 Cellular and Molecular Neuroscience Nerve Tissue Proteins Rodentia 610 Medicine & health Rats Receptors G-Protein-Coupled Mice Cellular and Molecular Neuroscience 3004 Pharmacology Reward 10054 Clinic for Psychiatry Psychotherapy and Psychosomatics Animals Health Expenditures |
| Popis: | Apathy, deficiency of motivation including willingness to exert effort for reward, is a common symptom in many psychiatric and neurological disorders, including depression and schizophrenia. Despite improved understanding of the neurocircuitry and neurochemistry underlying normal and deficient motivation, there is still no approved pharmacological treatment for such a deficiency. GPR139 is an orphan G protein-coupled receptor expressed in brain regions which contribute to the neural circuitry that controls motivation including effortful responding for reward, typically sweet gustatory reward. The GPR139 agonist TAK-041 is currently under development for treatment of negative symptoms in schizophrenia which include apathy. To date, however, there are no published preclinical data regarding its potential effect on reward motivation or deficiencies thereof. Here we report in vitro evidence confirming that TAK-041 increases intracellular Ca |
| Databáze: | OpenAIRE |
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