Novel m1 muscarinic agonists in treatment and delaying the progression of Alzheimer's disease: An unifying hypothesis
| Autor: | Orli Eisenberg, Yishai Karton, Daniele Marciano, Rachel Haring, Abraham Fisher, Zipora Pittel, Rachel Brandeis, Haim Meshulam, Eliahu Heldman, Nira Bar-Ner, Naomi Eshhar |
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| Rok vydání: | 1998 |
| Předmět: |
Amyloid
General Neuroscience Models Neurological Disease progression Disease Transfection Muscarinic Agonists Pharmacology Biology Amyloid beta-Protein Precursor Alzheimer Disease Cell culture Physiology (medical) Muscarinic acetylcholine receptor Disease Progression biology.protein Animals Humans Secretion Neuroscience Neurotrophin |
| Zdroj: | Journal of Physiology-Paris. 92:337-340 |
| ISSN: | 0928-4257 |
| DOI: | 10.1016/s0928-4257(99)80001-1 |
| Popis: | M1 selective agonists from the AF series (e.g. AF102B, AF150(S)), via m1 muscarinic receptors, activate distinct signal transductions, enhance amyloid precursors proteins secretion from transfected cells and primary cell cultures, show neurotrophic effects and are beneficial in a variety of animal models for Alzheimer's disease. Such m1 agonists may be effective in the treatment and therapy of Alzheimer's disease. |
| Databáze: | OpenAIRE |
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