Association of Exposure to Phthalates with Endometriosis and Uterine Leiomyomata: Findings from NHANES, 1999–2004

Autor: Stacey A. Missmer, Lauren A. Wise, Antonia M. Calafat, Jennifer Weuve, Russ Hauser
Rok vydání: 2010
Předmět:
endometriosis
mono(2-ethyl-5-hydroxyhexyl) phthalate
Adult
medicine.medical_specialty
Health
Toxicology and Mutagenesis
Uterine leiomyomata
Phthalic Acids
Endometriosis
Physiology
monobenzyl phthalate
di(2-ethylhexyl) phthalate
Surveys and Questionnaires
Internal medicine
Odds Ratio
medicine
Humans
mono(2-ethylhexyl) phthalate
Mono(2-ethyl-5-oxohexyl)phthalate
Uterine Neoplasm
monobutyl phthalate
Leiomyoma
business.industry
Research
Public Health
Environmental and Occupational Health
monoethyl phthalate
Monoethyl phthalate
Environmental Exposure
Environmental exposure
Middle Aged
leiomyomata
Nutrition Surveys
medicine.disease
mono(2-ethyl-5-oxohexyl) phthalate
Mono-(2-ethylhexyl)phthalate
United States
Cross-Sectional Studies
Logistic Models
Endocrinology
Uterine Neoplasms
Mono(2-ethyl-5-hydroxyhexyl) phthalate
dibutyl phthalate
Environmental Pollutants
Female
business
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
DOI: 10.1289/ehp.0901543
Popis: Background Phthalates are ubiquitous chemicals used in consumer products. Some phthalates are reproductive toxicants in experimental animals, but human data are limited. Objective We conducted a cross-sectional study of urinary phthalate metabolite concentrations in relation to self-reported history of endometriosis and uterine leiomyomata among 1,227 women 20–54 years of age from three cycles of the National Health and Nutrition Examination Survey (NHANES), 1999–2004. Methods We examined four phthalate metabolites: mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBP), monoethyl phthalate (MEP), and monobenzyl phthalate (MBzP). From the last two NHANES cycles, we also examined mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for potential confounders. Results Eighty-seven (7%) and 151 (12%) women reported diagnoses of endometriosis and leiomyomata, respectively. The ORs comparing the highest versus lowest three quartiles of urinary MBP were 1.36 (95% CI, 0.77–2.41) for endometriosis, 1.56 (95% CI, 0.93–2.61) for leiomyomata, and 1.71 (95% CI, 1.07–2.75) for both conditions combined. The corresponding ORs for MEHP were 0.44 (95% CI, 0.19–1.02) for endometriosis, 0.63 (95% CI, 0.35–1.12) for leiomyomata, and 0.59 (95% CI, 0.37–0.95) for both conditions combined. Findings for MEHHP and MEOHP agreed with findings for MEHP with respect to endometriosis only. We observed null associations for MEP and MBzP. Associations were similar when we excluded women diagnosed > 7 years before their NHANES evaluation. Conclusion The positive associations for MBP and inverse associations for MEHP in relation to endometriosis and leiomyomata warrant investigation in prospective studies.
Databáze: OpenAIRE
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