External validation of the HANDOC score – high sensitivity to identify patients with non-beta-haemolytic streptococcal endocarditis
| Autor: | Malene Højgaard Andersen, Henning Bundgaard, Niels Eske Bruun, Magnus Rasmussen, Torgny Sunnerhagen, Kasper Iversen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Infectious Medicine medicine.medical_specialty bacteraemia Denmark 030106 microbiology Bacteremia management score Sensitivity and Specificity Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus mitis Streptococcal Infections Medicine Endocarditis Humans echocardiography 030212 general & internal medicine Aged Aged 80 and over General Immunology and Microbiology biology business.industry Streptococcus streptococcus General Medicine Endocarditis Bacterial Middle Aged medicine.disease Streptococcus bovis biology.organism_classification Streptococcus sanguinis Infectious Diseases Blood Culture Infective endocarditis Cohort Female business Cohort study |
| Zdroj: | Sunnerhagen, T, Højgaard Andersen, M, Bruun, N E, Bundgaard, H, Iversen, K K & Rasmussen, M 2020, ' External validation of the HANDOC score – high sensitivity to identify patients with non-beta-haemolytic streptococcal endocarditis ', Infectious Diseases, vol. 52, no. 1, pp. 54-57 . https://doi.org/10.1080/23744235.2019.1679388 Infectious Diseases; 52(1), pp 54-57 (2020) |
| ISSN: | 2374-4235 |
| DOI: | 10.1080/23744235.2019.1679388 |
| Popis: | Background: Invasive infections with non-beta-haemolytic streptococci (NBHS) is quite common and presents the clinicians with difficulties regarding which patients are at risk for infective endocarditis (IE). The HANDOC score was developed to identify patients with NBHS bacteraemia who are at low risk of IE. This study was conducted to validate HANDOC in an external cohort. Methods: Patients with NBHS in blood cultures between March and September 2016 in a Danish centre were included as part of an on-going study. Patient characteristics were collected to classify bacteria according to Dukés criteria and the components of the HANDOC score were collected retrospectively from the patients’ medical records. Results: 68 patients were included in the cohort, of which 16 fulfilled Dukés criteria for IE. All patients with IE (16 of 16) had a HANDOC score above the predefined cut-off. Cases of IE were found in patients with. Streptococcus mitis, Streptococcus bovis, Streptococcus mutans, Streptococcus anginosus, and Streptococcus sanguinis group streptococci. The HANDOC score thus had a sensitivity of 100% and a specificity of 62% in this cohort. Conclusions: HANDOC has a sensitivity of 100% and a relatively high specificity (62%) also in a prospectively enrolled cohort of patients from another country than its origin. This indicates that HANDOC can be implemented in clinical practice to identify patients with a low risk of IE in whom echocardiography can be omitted. |
| Databáze: | OpenAIRE |
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