Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up
| Autor: | Anna Vasara, Teemu Paatela, Hannu Kautiainen, Ilkka Kiviranta, Jukka S. Jurvelin, Heikki Nurmi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cartilage
Articular medicine.medical_specialty 0206 medical engineering Biomedical Engineering Physical Therapy Sports Therapy and Rehabilitation 02 engineering and technology Transplantation Autologous Lesion 03 medical and health sciences Chondrocytes 0302 clinical medicine medicine Humans Immunology and Allergy Autologous chondrocyte implantation Clinical Research papers medicine.diagnostic_test business.industry Cartilage Arthroscopy Stiffness 030229 sport sciences medicine.disease Osteochondritis Dissecans 020601 biomedical engineering Osteochondritis dissecans Surgery Transplantation medicine.anatomical_structure Repair tissue medicine.symptom business Follow-Up Studies |
| Zdroj: | Cartilage |
| ISSN: | 1947-6043 1947-6035 |
| DOI: | 10.1177/1947603520921433 |
| Popis: | Objective. This study aims to describe biomechanical maturation process of repair tissue after cartilage repair with autologous chondrocyte implantation (ACI) at long-term follow-up. Design. After ACI, 40 patients underwent altogether 60 arthroscopic biomechanical measurements of the repair tissue at various time points during an up to 11-year follow-up period. Of these patients, 30 patients had full-thickness cartilage lesions and 10 had an osteochondritis dissecans (OCD) defect. The mean lesion area was 6.5 cm2 (SD 3.2). A relative indentation stiffness value for each individually measured lesion was calculated as a ratio of repair tissue and surrounding cartilage indentation value to enable interindividual comparison. Results. Repair tissue stiffness improved during approximately 5 years after surgery. Most of the increase in stiffness occurred during the first 2 years. The curvilinear correlation between relative stiffness values and the follow-up time was 0.31 (95% CI 0.07-0.52), P = 0.017. The interindividual variation of the stiffness was high. Lesion properties or demographic factors showed no significant correlation to biomechanical outcome. The overall postoperative average relative stiffness was 0.75 (SD 0.47). Conclusions. Our clinical study describes a biomechanical maturation process of cartilage repair that may continue even longer than expected. A substantial increase in tissue stiffness proceeds for the first two years postoperatively. Minor progression proceeds for even longer. In some repairs, the biomechanical result was equal to native cartilage, suggesting hyaline-type repair. The variation in biomechanical results suggests substantial inconsistency in the structural outcome following ACI. |
| Databáze: | OpenAIRE |
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