Catecholamine and serotonin depletion from rat spinal cord: Effects on morphine and footshock induced analgesia
| Autor: | Da Prada M, Alberto E. Panerai, Carruba Mo, E. Nisoli, Paola Sacerdote, Garosi |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Serotonin medicine.medical_specialty 5 7-Dihydroxytryptamine Central nervous system Serotonergic Hydroxydopamines Catecholamines Internal medicine Monoaminergic Animals Medicine Endogenous opioid Pharmacology Morphine business.industry Nociceptors Rats Inbred Strains Spinal cord Electric Stimulation Rats Nociception medicine.anatomical_structure Endocrinology Spinal Cord Female Opiate business |
| Zdroj: | Pharmacological Research. 25:187-194 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/1043-6618(92)91387-v |
| Popis: | Using a methodology that causes a selective degeneration of spinal cord catecholaminergic or serotoninergic pathways but not those of the brain, it has been possible to study more precisely the role played by the spinal cord monoaminergic systems that underly the mechanism through which morphine and endogenous opioids modulate nociceptive inputs. Both noradrenaline (NA) and serotonin (5-HT) appear to be involved: first, the noradrenergic and only subsequently, with higher doses of the opiate, the serotoninergic pathways. |
| Databáze: | OpenAIRE |
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