Silk fibroin/hydroxyapatite scaffold: a highly compatible material for bone regeneration
| Autor: | Sidra Rasheed, Chen Yougen, Muhammad Saleem |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Artificial bone 211 Scaffold / Tissue engineering/Drug delivery Materials science Biocompatibility 102 Porous / Nanoporous / Nanostructured materials Fibroin 02 engineering and technology scaffold 010402 general chemistry Bone tissue 01 natural sciences 301 Chemical syntheses / processing bone regeneration Tissue engineering medicine General Materials Science Bone regeneration Materials of engineering and construction. Mechanics of materials Organic and Soft Materials (Colloids Liquid Crystals Gel Polymers) 103 Composites Regeneration (biology) hydroxyapatite 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure silk fibroin TA401-492 0210 nano-technology TP248.13-248.65 biomaterials Biotechnology Biomedical engineering |
| Zdroj: | Science and Technology of Advanced Materials, Vol 21, Iss 1, Pp 242-266 (2020) Science and Technology of Advanced Materials |
| ISSN: | 1878-5514 1468-6996 |
| DOI: | 10.1080/14686996.2020.1748520 |
| Popis: | In recent years remarkable efforts have been made to produce artificial bone through tissue engineering techniques. Silk fibroin (SF) and hydroxyapatite (HA) have been used in bone tissue regeneration as biomaterials due to mechanical properties of SF and biocompatibility of HA. There has been growing interest in developing SF/HA composites to reduce bone defects. In this regard, several attempts have been made to study the biocompatibility and osteoconductive properties of this material. This article overviews the recent advance from last few decades in terms of the preparative methods and application of SF/HA in bone regeneration. Its first part is related to SF that presents the most common sources, preparation methods and comparison of SF with other biomaterials. The second part illustrates the importance of HA by providing information about its production and properties. The third part presents comparative studies of SF/HA composites with different concentrations of HA along with methods of preparation of composites and their applications. Graphical abstract |
| Databáze: | OpenAIRE |
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