Further evidence that severe scores in the aggression/anxiety-depression/attention subscales of child behavior checklist (severe dysregulation profile) can screen for bipolar disorder symptomatology: a conditional probability analysis
| Autor: | Janet Wozniak, K. Yvonne Woodworth, Thomas J. Spencer, Tara Kenworthy, Mai Uchida, MaryKate Martelon, Joseph Biederman, Stephen V. Faraone |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Adolescent Poison control CBCL Article mental disorders medicine Humans Attention deficit hyperactivity disorder Bipolar disorder Child Child Behavior Checklist Psychiatry Probability Psychiatric Status Rating Scales Depressive Disorder Odds ratio medicine.disease Anxiety Disorders Checklist Aggression Psychiatry and Mental health Clinical Psychology Mood disorders Attention Deficit Disorder with Hyperactivity Female Psychology Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 165:81-86 |
| ISSN: | 0165-0327 |
| Popis: | Previous work shows that children with high scores (2SD, combined score≥210) on the Attention Problems, Aggressive Behavior, and Anxious-Depressed (A-A-A) subscales of the Child Behavior Checklist (CBCL) are more likely than other children to meet criteria for bipolar (BP)-I disorder. However, the utility of this profile as a screening tool has remained unclear.We compared 140 patients with pediatric BP-I disorder, 83 with attention deficit hyperactivity disorder (ADHD), and 114 control subjects. We defined the CBCL-Severe Dysregulation profile as an aggregate cutoff score of ≥210 on the A-A-A scales. Patients were assessed with structured diagnostic interviews and functional measures.Patients with BP-I disorder were significantly more likely than both control subjects (Odds Ratio [OR]: 173.2; 95% Confidence Interval [CI], 21.2 to 1413.8; P0.001) and those with ADHD (OR: 14.6; 95% CI, 6.2 to 34.3; P0.001) to have a positive CBCL-Severe Dysregulation profile. Receiver Operating Characteristics analyses showed that the area under the curve for this profile comparing children with BP-I disorder against control subjects and those with ADHD was 99% and 85%, respectively. The corresponding positive predictive values for this profile were 99% and 92% with false positive rates of0.2% and 8% for the comparisons with control subjects and patients with ADHD, respectively.Non-clinician raters administered structured diagnostic interviews, and the sample was referred and largely Caucasian.The CBCL-Severe Dysregulation profile can be useful as a screen for BP-I disorder in children in clinical practice. |
| Databáze: | OpenAIRE |
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