Differences between endocarditis caused by Streptococcus bovis and Enterococcus spp. and their association with colorectal cancer
| Autor: | Fernando García-Garrote, M. J. López-Álvarez, Ramón Rabuñal, M. P. Alonso-García, A. Coira, J. Corredoira, Miguel Blanco, L. Lopez-Roses, A. Rodriguez-Macias, J. Pita, M. J. García-País |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Colorectal cancer Colonoscopy Gastroenterology Medical microbiology Internal medicine medicine Humans Endocarditis Gram-Positive Bacterial Infections Aged Retrospective Studies Aged 80 and over biology medicine.diagnostic_test Retrospective cohort study Endocarditis Bacterial General Medicine Middle Aged Streptococcus bovis biology.organism_classification medicine.disease Surgery Infectious Diseases Bacteremia Concomitant Female Colorectal Neoplasms Enterococcus Follow-Up Studies |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 34:1657-1665 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-015-2402-1 |
| Popis: | Streptococcus bovis group and Enterococcus spp. share phenotypic characteristics and intestinal habitat. Both have been associated with endocarditis and colorectal neoplasm (CRN). We studied all cases of endocarditis diagnosed between 1988 and 2014 in our centre and caused by S. bovis (109, 48.8 % of the bacteremia) and by Enterococcus spp. (36, 3.4 % of the bacteremia). Patients were seen until death or during a long-term follow-up, in order to rule out a concomitant CRN. The 109 cases of S. bovis endocarditis (SbIE) compared with the 36 caused by enterococci showed: a higher proportion of males (91 % vs. 72 %, p=0.005), more multivalvular involvement (28 % vs. 6 %, p=0.004), embolic complications (44 vs. 22 %, p=0.02) and colorectal neoplasm (64 % vs. 25 %, p=0.001). SbIE showed fewer co-morbidities (32 vs. 58 %, p=0.005), and less frequently urinary infection source (0 vs. 25 %, p=0.001) and healthcare-related infection (2 vs. 44 %, p=0.001). A total of 123 patients were followed up for an extended period (mean: 65.9 ± 57.5 months). During the follow-up, 6 of 28 (21 %) cases with enterococcal endocarditis and 43 of 95 (45.2 %, p=0.01) cases with SbIE developed a new CRN. These neoplasiae appeared a mean of 60.4 months later (range 12-181 months). Among the 43 cases with SbIE and CRN, 12 had had a previously normal colonoscopy and 31 had had a previous CRN and developed a second neoplasm. Cases of SbIE present important differences with those caused by Enterococcus spp. Colonoscopy must be mandatory both in the initial evaluation of SbIE, as during the follow-up period. |
| Databáze: | OpenAIRE |
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