The application of NIR spectroscopy with chemometric analysis for monitoring a powder blending process
| Autor: | J Irena Homsek, M Aleksandar Nikolic, D Slobodan Petrovic, D Branislav Jovic, B Ljiljana Maric |
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| Rok vydání: | 2014 |
| Předmět: |
Chromatography
Materials science Process analytical technology Analytical technique Near-infrared spectroscopy Analytical chemistry NIR spectroscopy General Chemistry Metformin Hydrochloride PLS Dosage form blend uniformity analysis lcsh:Chemistry lcsh:QD1-999 Critical parameter Partial least squares regression Spectroscopy metformin hydrochloride PAT |
| Zdroj: | Journal of the Serbian Chemical Society Journal of the Serbian Chemical Society, Vol 79, Iss 3, Pp 331-340 (2014) |
| Popis: | This paper reports the use of near infrared (NIR) spectroscopy as a process analytical technology (PAT) tool for monitoring the metformin (N,N-dimethylimidodicarbonimidic diamide) hydrochloride and poly(vinyl pyrrolidone) (PVP) mixing process, which is the first stage in tablet production. Blend homogeneity was tested using the non-invasive NIR spectroscopy method and the partial least squares (PLS) regression model was applied for the analysis of the obtained spectra. Simultaneously, the critical parameter (metformin hydrochloride content) was monitored by a classical analytical technique, the validated HPLC method, commonly used for this purpose. Based on the high sensitivity of the model developed in this study, as well as the established correlation among the results obtained by different methods, it could be concluded that the proposed rapid and non-invasive technique. could be an effecttive tool for the monitoring of one of the critical manufacturing steps in the production solid dosage forms. |
| Databáze: | OpenAIRE |
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