Unexpectedly High Prevalence of Cystoisospora belli Infection in Acalculous Gallbladders of Immunocompetent Patients
| Autor: | Philip J. Katzman, Laura W. Lamps, Mushal Noor, Michael G. Drage, Christa L. Whitney-Miller, Jennifer J. Findeis-Hosey, Aaron R Huber, Zhongren Zhou, Raul S. Gonzalez, Kathryn Skonick, Henriette D N’kodia, Rebecca Abell, Lawrence J. Saubermann |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Gallbladder Diseases Gastroenterology Cohort Studies 03 medical and health sciences symbols.namesake Young Adult 0302 clinical medicine Internal medicine medicine Prevalence Humans Cholecystectomy Cystoisospora belli Prospective Studies Prospective cohort study Fisher's exact test Retrospective Studies Retrospective review High prevalence biology business.industry Coccidiosis Gallbladder Retrospective cohort study General Medicine Original Articles Middle Aged biology.organism_classification Coccidia medicine.anatomical_structure 030220 oncology & carcinogenesis symbols 030211 gastroenterology & hepatology Female business |
| Zdroj: | American Journal of Clinical Pathology |
| ISSN: | 1943-7722 |
| Popis: | Objectives Indications for cholecystectomy have changed dramatically over the past three decades. Cystoisospora belli has been reported in cholecystectomy specimens of immunocompetent patients. The present study was designed to determine the prevalence and clinical association of C belli in the gallbladder. Methods The study included retrospective review of cholecystectomy specimens (n = 401) removed for various indications, and a prospective cohort of cholecystectomy specimens (n = 22) entirely submitted for histologic evaluation. Correlations of presence of C belli with age, sex, clinical indication, and abnormalities of preoperative laboratory values were assessed by Fisher exact test. Results C belli was identified in 39/401 (9.7%) of the retrospective cohort, and 6/22 (27.3%) of the entirely submitted specimens. The presence of C belli showed no correlation with age, sex, clinical indication, or laboratory abnormalities. Conclusions C belli resides in a latent state in the gallbladder and may be best considered a commensal organism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|