Large joint and lower extremity involvement have higher impact on disease outcomes in oligoarticular psoriatic arthritis
Autor: | Ozun Bayindir, Cem Ozisler, Kenan Aksu, Ahmet Omma, Orhan Küçükşahin, Gizem Ayan, Sibel Bakirci, Atalay Dogru, Mehmet Tuncay Duruöz, Umut Kalyoncu, Sule Yavuz, Sibel Zehra Aydin, Meryem Can, Levent Kilic, Dilek Solmaz, Ilaria Tinazzi, Emine Figen Tarhan, Gezmiş Kimyon |
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Přispěvatelé: | Ege Üniversitesi |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Canada Turkey Patient-Reported Outcomes Disease outcome Psoriatic Arthritis 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Rheumatology International database Predictive Value of Tests Internal medicine Medicine Humans In patient 030212 general & internal medicine Patient Reported Outcome Measures Registries Physical Examination 030203 arthritis & rheumatology Oligoarthritis business.industry Arthritis Psoriatic Swollen joints Mean age Middle Aged medicine.disease Prognosis C-Reactive Protein Cross-Sectional Studies Italy Lower Extremity Large joint Female Joints business |
Popis: | Objective Joints with different sizes and anatomical locations can be affected in psoriatic arthritis (PsA). Our aim was to explore the effect of different joint patterns on patient-reported outcomes (PROs) in patients with mono-oligoarthritis. Methods Within PsArt-ID (Psoriatic Arthritis- International Database), 387/1670 patients who had mono-oligoarthritis (1-4 tender and swollen joints) were enrolled in cross-sectional assessment. the joints were categorized according to their size (small/large) and location (upper/lower extremity) and PROs, physician global assessment and C-reactive protein (CRP) were compared. Analysis was made by categorizing according to joint counts (1-2 joints/ 3-4 joints). Results the mean age (SD) was 46.9 (14.24) with a mean (SD) PsA duration of 3.93 (6.03) years. Within patients with 1-2 involved joints (n = 302), size of the joints only had an impact on CRP values with large joints having higher CRP (P = .005), similar to lower extremity involvement (P = .004). PROs were similar regardless of size or location if 1-2 joints were inflamed. Within patients with 3-4 involved joints (n = 85), patient global assessment (PGA), pain, fatigue and physician global assessment were higher in the group with large joints. Similarly, PGA, pain, and physician global assessment were higher in patients with lower extremity involvement as well as higher CRP values. Conclusion For PsA patients with 3-4 joints involved, lower extremity and large joints are associated with poorer outcomes with worse PROs, physician global assessment, and higher CRP. the size and anatomical location of the joints are less important for patients with 1-2 joints in terms of the PROs. Union Chimique Belge (UCB); Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) This work was supported by the Union Chimique Belge (UCB) (to Dilek Solmaz for axial spondyloarthritis fellowship) and the Scientific and Technological Research Council of Turkey (TUBITAK) (to Sibel Bakirci). |
Databáze: | OpenAIRE |
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