Progesterone and estradiol suppress human mononuclear cell cytotoxicity
| Autor: | Scott W. Walsh, Nenita S. Tan, Peter C. Brath, Bernard Gonik, Bruce B. Feinberg |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cytotoxicity
Immunologic medicine.medical_specialty medicine.drug_class Immunology Estrone Biology Peripheral blood mononuclear cell chemistry.chemical_compound Internal medicine Progesterone receptor medicine Immunology and Allergy Humans Cytotoxicity reproductive and urinary physiology Cells Cultured Progesterone Dose-Response Relationship Drug Estradiol Obstetrics and Gynecology Trophoblast Estriol Drug Synergism Cytotoxicity Tests Immunologic Trophoblasts Mifepristone medicine.anatomical_structure Endocrinology Reproductive Medicine chemistry Estrogen embryonic structures Pregnenolone Leukocytes Mononuclear Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of reproductive immunology. 21(2) |
| ISSN: | 0165-0378 |
| Popis: | Fetal trophoblast is generally resistant to lysis by cytotoxic cells. We hypothesized that progesterone and estrogens secreted by the trophoblast act at the choriodecidual interface where they are present in high concentrations to provide a local, paracrine immunosuppressive effect on cellular cytotoxicity. Using peripheral blood mononuclear cells as effector cells in a cytotoxicity assay, we evaluated the effects of progesterone, estrone, estradiol and estriol, either alone or in combination, on cellular cytotoxicity. Both progesterone and estradiol suppressed cytotoxicity in a dose-dependent manner. Estrone, estriol, pregnenolone and cholesterol had no effect. A synergistic suppression of cytotoxicity was observed when estrone, estradiol, estriol and progesterone were combined. We speculate that trophoblast production of progesterone and estradiol may be an important local immunosuppressive mechanism contributing to fetal survival. |
| Databáze: | OpenAIRE |
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