[Reproductive and developmental toxicity study of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187). (II)--Oral administration to rats during the period of fetal organogenesis (prenatal examination)
| Autor: | Yasuki Yokomoto, Kazuyoshi Watanabe, Keitaro Terazawa, Akira Maruden, Norio Hasegawa, Mikio Terabayashi, Shigeru Kuramoto, Kazunori Shimamura, Kyoko Otani |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Period (gene) Developmental toxicity Administration Oral Organogenesis Prenatal examination Toxicology Dose level Rats Sprague-Dawley Embryonic and Fetal Development Fetus Oral administration Pregnancy Internal medicine medicine Animals Maternal-Fetal Exchange business.industry Cesarean Section Reproduction Body Weight Imidazoles Rats Endocrinology Gestation Female business |
| Zdroj: | The Journal of toxicological sciences. 17 |
| ISSN: | 0388-1350 |
| Popis: | 6-Amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl) amino] benzoate dimethanesulfonate (FUT-187) was given orally to pregnant Crj : CD (Sprague-Dawley) rats from days 7 through 17 of gestation at dose levels of 50, 200 and 800 mg/kg/day. In the 800 mg/kg/day group, salivation just after dosing, suppression in body weight gain and decreased food consumption were observed. No external, visceral and skeletal anomalies attributable to FUT-187 were observed in fetuses. From the present result, it is considered that the no-effect dose level of FUT-187 for dams and fetuses are 200 mg/kg/day and 800 mg/kg/day respectively. |
| Databáze: | OpenAIRE |
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