Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis
| Autor: | Claudio Bassi, Giorgio Zamboni, A. Scarpa, Nicholas R. Lemoine, Ps Moore, S Orlandini, P Capelli, G Rigaud, Massimo Falconi |
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| Přispěvatelé: | Moore, P, Orlandini, S, G., Zamboni, Capelli, P, Rigaud, G, Falconi, Massimo, Bassi, C, Lemoine, N, Scarpa, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Acinar Cell/genetics/metabolism/pathology Carcinoma
p53 Cancer Research Exocrine gland Pancreatic disease DPC4/Smad4 DNA Mutational Analysis Loss of Heterozygosity p16 carcinoma Infiltrating Duct/genetics/metabolism/pathology Carcinoma microsatellites acinar cancer pancreas Polymorphism Single-Stranded Conformational Endocrine gland neoplasm Smad4 Protein Carcinoma Ductal Breast Ampulla of Vater Regular Article Adenocarcinoma Mucinous Immunohistochemistry Pancreatic Ductal/genetics/metabolism/pathology Carcinoma DNA-Binding Proteins medicine.anatomical_structure Oncology Adenocarcinoma Pancreas Carcinoma Pancreatic Ductal Pancreatic tumour endocrine tumor Common Bile Duct Neoplasms tumorigenesis Biology endocrine tumour Exocrine Glands Mucinous/genetics/metabolism/pathology Base Sequence Carcinoma ampulla of Vater cancer Endocrine Glands Endocrine Gland Neoplasms medicine Humans intraductal papillary-mucinous tumour K-ras allelotyping Cyclin-Dependent Kinase Inhibitor p16 solid pseudopapillary tumour Base Sequence Papillary/genetics/metabolism/pathology Common Bile Duct Neoplasms/genetics/metabolism/pathology DNA/chemistry/genetics DNA Mutational Analysis Carcinoma Acinar Cell Cancer DNA Ductal carcinoma medicine.disease ductal cancer Carcinoma Papillary digestive system diseases Pancreatic Neoplasms Mutation Trans-Activators ras Proteins Cancer research Tumor Suppressor Protein p53 molecular pathways |
| Zdroj: | British Journal of Cancer |
| Popis: | Alterations of K-ras, p53, p16 and DPC4/Smad4 characterize pancreatic ductal cancer (PDC). Reports of inactivation of these latter two genes in pancreatic endocrine tumours (PET) suggest that common molecular pathways are involved in the tumorigenesis of pancreatic exocrine and endocrine epithelia. We characterized 112 primary pancreatic tumours for alterations in p16 and DPC4 and immunohistochemical expression of DPC4. The cases included 34 PDC, 10 intraductal papillary-mucinous tumours (IPMT), 6 acinar carcinomas (PAC), 5 solid-pseudopapillary tumours (SPT), 16 ampulla of Vater cancers (AVC) and 41 PET. All tumours were also presently or previously analysed for K- ras and p53 mutations and allelic loss at 9p, 17p and 18q. Alterations in K- ras, p53, p16 and DPC4 were found in 82%, 53%, 38% and 9% of PDC, respectively and in 47%, 60%, 25% and 6% of AVC. Alterations in these genes were virtually absent in PET, PAC or SPT, while in IPMT only K-ras mutations were present (30%). Positive immunostaining confirmed the absence of DPC4 alterations in all IPMT, SPT, PAC and PET, while 47% of PDC and 38% of AVC were immunonegative. These data suggest that pancreatic exocrine and endocrine tumourigenesis involves different genetic targets and that among exocrine pancreatic neoplasms, only ductal and ampullary cancers share common molecular events. © 2001 Cancer Research Campaign http://www.bjcancer.com |
| Databáze: | OpenAIRE |
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