Effects of an intensive lifestyle intervention and the role of sleep in people living with HIV and prediabetes: a pilot and feasibility study

Autor: Chatvara Areevut, Wanabhorn Tongchom, Supaporn Somwang, Nampeth Saibuathong, Angsana Phuphuakrat, Sunee Saetung, Amornrat Hathaidechadusadee, Hataikarn Nimitphong, Ratanaporn Jerawatana, Jandanee Sakmanarit, Sirimon Reutrakul, Orawan Pichitchaipitak, Somnuek Sungkanuparph
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Blood Glucose
Male
Abnormal glucose
Science (General)
Human immunodeficiency virus (HIV)
HIV Infections
Pilot Projects
medicine.disease_cause
Q1-390
0302 clinical medicine
Medicine
030212 general & internal medicine
Prediabetes
Biology (General)
education.field_of_study
General Medicine
Middle Aged
Sleep in non-human animals
Research Note
Female
Adult
medicine.medical_specialty
Diabetes risk
QH301-705.5
Population
030209 endocrinology & metabolism
Intensive lifestyle intervention
General Biochemistry
Genetics and Molecular Biology
Prediabetic State
03 medical and health sciences
Internal medicine
Lifestyle intervention
Humans
Healthy Lifestyle
education
Exercise
Life Style
Aged
business.industry
HIV
medicine.disease
Diet
Cross-Sectional Studies
Metabolic control analysis
Feasibility Studies
business
Sleep
Zdroj: BMC Research Notes, Vol 14, Iss 1, Pp 1-8 (2021)
BMC Research Notes
ISSN: 1756-0500
Popis: Objectives Prediabetes is prevalent in people living with HIV (PLWH). Insufficient and irregular sleep are linked to abnormal glucose metabolism. This study aimed to investigate the differences in sleep characteristics between PLWH with and without prediabetes, determine the acceptability/feasibility and effects of a pilot six-month intensive lifestyle intervention (ILI) program on glucose metabolism in those with prediabetes, and determine how sleep modulates these effects. Results Thirty-nine PLWH (20 normoglycemia and 19 prediabetes) participated. There were no differences in sleep characteristics between individuals with normoglycemia and prediabetes. Next, thirteen individuals with prediabetes completed a six-month ILI program. The ILI program resulted in significant body weight reduction at 6 months (63.5 ± 13.9 to 61.9 ± 14.0 kg, p = 0.012), which was maintained at 12 months (p p = 0.014). An increase in sleep variability was significantly associated with an increase in 2-h plasma glucose, independent of changes in BMI (b = 0.603), and physical activity (b = 0.774). This pilot study suggested that ILI in PLWH with prediabetes is feasible and effective in improving metabolic control, with its effects possibly modulated by sleep variability. These findings should be confirmed in a larger study to reduce diabetes risk in this population. Trail registration: ClinicalTrial.gov, NCT03545217 (date of registration: May 22, 2018)
Databáze: OpenAIRE
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