Cardiac response to norepinephrine and sympathetic nerve stimulation following experimental subarachnoid hemorrhage
| Autor: | Elisabeth Lambert, Gavin W. Lambert, Elodie Percy, Xiao-Jun Du |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Subarachnoid hemorrhage Stimulation Cisterna magna Ventricular Function Left Rats Sprague-Dawley Norepinephrine (medication) Norepinephrine Internal medicine Receptors Adrenergic beta Animals Medicine Sympathoadrenal system cardiovascular diseases Sympathomimetics medicine.diagnostic_test business.industry Myocardium Arrhythmias Cardiac Heart Subarachnoid Hemorrhage medicine.disease Electric Stimulation Rats medicine.anatomical_structure Endocrinology Neurology Ventricle Ventricular pressure Neurology (clinical) business Electrocardiography medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 198:43-50 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(02)00073-4 |
| Popis: | This study aimed to investigate the cardiac response to sympathetic stimulation and norepinephrine exposure following subarachnoid hemorrhage (SAH). Cardiac functional response was assessed 3 days following an injection of 300 microl of homologous blood in the cisterna magna using an in situ perfused, innervated rat heart model. Sympathetic nervous activity was indirectly assessed from measurements of arterial plasma and tissue norepinephrine concentration and cardiac beta-receptor density. In in situ perfused hearts, sympathetic nerve stimulation (2, 4 and 8 Hz, 1 min duration) induced a frequency-dependent increase in left ventricular pressure (VP), with the response being more pronounced in the SAH group of animals at the higher frequency (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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