Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy
| Autor: | K L King, J Rullamas, Diane Pennica, D S Knutzon, Shiuh-Ming Luoh, E Luis, Kenneth R. Chien, K J Shaw, R Yen, W C Darbonne |
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| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Cardiotrophin 1 Molecular Sequence Data Cardiomegaly Ciliary neurotrophic factor Muscle hypertrophy Mice Internal medicine medicine Animals Humans Amino Acid Sequence Cloning Molecular Interleukin 6 Cells Cultured Multidisciplinary Base Sequence Sequence Homology Amino Acid biology Cardiac myocyte Oncostatin M DNA Glycoprotein 130 Rats Cell biology Endocrinology biology.protein Cytokines Leukemia inhibitory factor Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 92:1142-1146 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.92.4.1142 |
| Popis: | Heart failure continues to be a leading cause of mortality worldwide. A hallmark of this disease is dilated cardiac hypertrophy, which is accompanied by a reactivation of genes expressed in fetal heart development. Reasoning that fetal or embryonic growth factors may mediate the onset of cardiac hypertrophy, we have coupled expression cloning with an embryonic stem cell-based model of cardiogenesis to isolate a 21.5-kDa protein, cardiotrophin 1, that potently induces cardiac myocyte hypertrophy in vitro. Amino acid similarity data indicate that cardiotrophin 1 is a member of the leukemia inhibitory factor/ciliary neurotrophic factor/oncostatin M/interleukin 6/interleukin 11 family of cytokines. Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. A 1.4-kb cardiotrophin 1 mRNA is expressed in the heart and several other mouse tissues. |
| Databáze: | OpenAIRE |
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