Insulin autoimmune syndrome
| Autor: | Evgeny Vasilyev, Marina Yukina, Nurana Nuralieva, Ekaterina Troshina, Maksim Solovyev |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
C-peptide (blood)
Endocrinology Diabetes and Metabolism medicine.medical_treatment White Disease Anxiety Protein electrophoresis lcsh:Diseases of the endocrine glands. Clinical endocrinology 0302 clinical medicine Russian Federation Insulin HLA genotyping alpha-lipoic acid Glucose (blood fasting) Multiple myeloma Diabetes 030220 oncology & carcinogenesis Female Thioctic acid New Disease or Syndrome: Presentations/Diagnosis/Management Proinsulin Adult Insulin (fasting) 030209 endocrinology & metabolism Human leukocyte antigen Glucose (blood) Urinalysis Dizziness Glucose (blood postprandial) 03 medical and health sciences Pharmacotherapy Exercise tolerance Diabetes mellitus Internal Medicine medicine HOMA Glucose tolerance (oral) Pancreas June lcsh:RC648-665 business.industry Albumin Autoantibody medicine.disease Immunoglobulin A Anti-insulin antibodies Thyroid ultrasonography Immunology business Hypoglycaemia Insulin Autoimmune Syndrome Monoclonal gammopathy of undetermined significance |
| Zdroj: | Endocrinology, Diabetes & Metabolism Case Reports Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-6 (2020) |
| ISSN: | 2052-0573 |
| Popis: | Summary Insulin autoimmune syndrome (Hirata’s disease) is a disorder caused by development of autoantibodies to insulin and manifested by hypoglycaemic syndrome. The overwhelming majority of physicians do not include it in the differential diagnosis of hypoglycaemic states because of a misconception of an extremely low prevalence of this condition. This results in unnecessary drug therapy and unjustified surgical interventions in patients that otherwise would be successfully treated conservatively. This disease is strongly associated with certain alleles of the HLA gene. In most cases, this condition develops in predisposed individuals taking drugs containing sulfhydryl groups. Formation of autoantibodies to insulin may be observed in patients with other autoimmune disorders, as well as in those with multiple myeloma or monoclonal gammopathy of undetermined significance. This paper presents the first Russian case report of insulin autoimmune syndrome in an adult patient. Learning points: Insulin autoimmune syndrome, Hirata’s disease, anti-insulin antibodies, and hypoglycaemia. |
| Databáze: | OpenAIRE |
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