Serotonergic Studies in Patients With Affective and Personality Disorders
| Autor: | Larry J. Siever, Karen Cochrane, Kenneth L. Davis, Coccaro Ef, Richard C. Mohs, Howard Klar, Gail Maurer, Thomas B. Cooper |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty Fenfluramine media_common.quotation_subject Poison control Suicide Attempted Serotonergic Personality Disorders Fenfluramine Hydrochloride Arts and Humanities (miscellaneous) medicine Humans Personality Psychiatry Depression (differential diagnoses) media_common Psychiatric Status Rating Scales Depressive Disorder Suicide attempt Middle Aged medicine.disease Personality disorders Prolactin Aggression Alcoholism Psychiatry and Mental health Impulsive Behavior Serotonin Antagonists Psychology Clinical psychology medicine.drug |
| Zdroj: | Archives of General Psychiatry. 46:587 |
| ISSN: | 0003-990X |
| Popis: | Dysfunction of the central serotonergic system has been variously associated with depression and with suicidal and/or impulsive aggressive behavior. To evaluate central serotonergic function in relation to these variables, prolactin responses to a single-dose challenge with fenfluramine hydrochloride (60 mg orally), a serotonin releasing/uptake-inhibiting agent, were examined in 45 male patients with clearly defined major affective (n = 25) and/or personality disorder (n = 20) and in 18 normal male control patients. Prolactin responses to fenfluramine among all patients were reduced compared with responses of controls. Reduced prolactin responses to fenfluramine were correlated with history of suicide attempt in all patients but with clinician and self-reported ratings of impulsive aggression in patients with personality disorder only; there was no correlation with depression. These results suggest that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in patients with personality disorder only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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