Hyperoxia-Induced Protection against Rat's Renal Ischemic Damage: Relation to Oxygen Exposure Time

Autor:	Mahmood Mofid, Hassan Mohammadhosseniakbari, Alireza Asgai, Hannaneh Wahhabaghai, Bahram Rasoulian, Mahvash Jafari, Mohsen Foadoddini, Mansour Esmaili, Ali Khoshbaten, Hossein Mehrani, Majid Noroozi
Rok vydání:	2009
Předmět:	Male Nephrology medicine.medical_specialty Time Factors Fractional excretion of sodium Urinary system Ischemia Renal function Hyperoxia Kidney Kidney Function Tests Critical Care and Intensive Care Medicine Random Allocation Malondialdehyde Internal medicine medicine Animals Rats Wistar Ischemic Preconditioning Blood urea nitrogen Probability Analysis of Variance business.industry General Medicine Catalase medicine.disease Immunohistochemistry Rats Oxygen Disease Models Animal Oxidative Stress Endocrinology medicine.anatomical_structure Regional Blood Flow Creatinine Reperfusion Injury Anesthesia Kidney Diseases medicine.symptom Reactive Oxygen Species business
Zdroj:	Renal Failure. 31:514-521
ISSN:	1525-6049 0886-022X
DOI:	10.1080/08860220902963863
Popis:	Pre-exposure to hyperoxic gas (or= 95%) has been shown to protect the heart and central nervous system from ischemia-reperfusion injury. In the present study, we investigated whether oxygen pretreatment induces delayed renal protection in rats. The possible role of some renal antioxidant agents was also investigated.Adult male Wistar rats were kept in a hyperoxic (HO) (or= 95% O(2)) environment for 0.5 h, 1 h, 2 h, 3 h, 6 h, and 2 h/day for three consecutive days and 4 h/day for six consecutive days, and control group (IR) animals were kept in the cage with no HO, one day before subjecting their kidney to 40 minutes of ischemia and 24h of reperfusion. Renal function was assessed by comparing plasma creatinine (Cr), blood urea nitrogen (BUN), creatinine clearance (CLCr), and fractional excretion of sodium (FENa%). Histopathological injury score was also determined according to the Jablonski method. To examine the antioxidant system induction by hyperoxia, we measured renal catalase and superoxide dismutase activity, and renal glutathione and malondialdehyde content.Our data demonstrated that only in 4 h/day HO for six consecutive days, the renal function tests (Cr, CLCr, BUN, and FENa%) and Jablonski histological injury were better than control group (p0.05). The beneficial effect of oxygen pretreatment in this group was associated with increased renal catalase activity compared with those obtained from control group (p0.05).The present study demonstrates that repeated exposure to hyperoxic (or= 95% O(2)) environment can reduce subsequent rat's renal ischemia-reperfusion damage. Induction of endogenous antioxidant system may partially explain this beneficial effect of hyperoxic preconditioning.
Databáze:	OpenAIRE
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