Assessment of microheterogeneity of blood flow in the rat urinary bladder by high-resolution digital radiography
| Autor: | Atsushi Takenaka, Tokunori Yamamoto, Atsushi Sone, Takahiro Kimura, Masato Fujisawa |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Detrusor muscle Pathology medicine.medical_specialty Urinary bladder business.industry Microcirculation Urology Coefficient of variation Urinary system Urinary Bladder Hemodynamics Blood flow Rats Radiography Muscular layer medicine.anatomical_structure Animals Medicine Rats Wistar business Nuclear medicine Blood Flow Velocity |
| Zdroj: | BJU International. 95:895-897 |
| ISSN: | 1464-410X 1464-4096 |
| DOI: | 10.1111/j.1464-410x.2005.05423.x |
| Popis: | OBJECTIVES To assess high-resolution digital radiography for measuring blood flow and thus examine the microheterogeneity of bladder microcirculation in a rat model. MATERIALS AND METHODS Microheterogeneity of blood flow in both mucosa and detrusor muscle of eight anaesthetized rats was investigated using an imaging technique with very high spatial resolution (0.1 × 0.1 mm2) using digital radiography combined with the deposition of 3H-labelled desmethylimipramine. The spatial pattern of blood flow was quantified by the coefficient of variation of the regional flow (CV = sd/mean). RESULTS Muscle blood flow was less than mucous blood flow (muscle : mucosa, 2.9 : 5) in the empty bladder. In the muscle layer the blood flow distribution was more heterogeneous than that in the mucosa, with a mean (sd) CV in muscle and mucosa of 0.33 (0.033) and 0.16 (0.019), respectively (P |
| Databáze: | OpenAIRE |
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