US deceased kidney transplantation: Estimated GFR, donor age and KDPI association with graft survival
| Autor: | David K. Klassen, Timothy L. Pruett, Robert J. Carrico, Gabriel R. Vece |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
DCD
donation after circulatory death KDPI kidney donor profile index medicine.medical_specialty Medicine (General) HRSA Health Resources and Services Administration Agency within HHS medicine.medical_treatment Urology Renal function Outcomes AUC area under curve 01 natural sciences End stage renal disease 03 medical and health sciences 0302 clinical medicine Age R5-920 Glomerular filtration rate (GFR) Medicine OPTN Organ Procurement and Transplantation Network 030212 general & internal medicine 0101 mathematics eGFR-1 one year after transplantation Kidney transplantation Dialysis KDRI kidney donor risk index Kidney Transplantation business.industry urogenital system CKD chronic kidney disease CKD-EPI Chronic Kidney Disease Epidemiology Collaboration Equation eGFR estimated glomerular filtration rate 010102 general mathematics CPRA calculated panel-reactive antibody General Medicine medicine.disease Donation CI Confidence Interval KDIGO Kidney Disease Improving Global Outcomes Confidence interval HHS Department of Health and Human Services of the US government medicine.anatomical_structure surgical procedures operative ESRD end stage renal disease Cohort business Research Paper |
| Zdroj: | EClinicalMedicine, Vol 37, Iss, Pp 100980-(2021) EClinicalMedicine |
| ISSN: | 2589-5370 |
| Popis: | Background: Despite a significant shortage of kidneys for transplantation in the US, kidneys from older deceased donors are infrequently transplanted. This is primarily over concern of graft quality and transplant durability. Methods: The US national transplant database (2000–2018) was assessed for deceased donor kidney transplant patient and graft survival, graft durability and stratified by donor age (), Kidney Donor Profile Index (KDPI) and estimated glomerual filtration rate (GFR) one year post-transplantation (eGFR-1) were calculated. Findings: Recipients of kidneys transplanted from deceased donors >65 years had a lower eGFR-1, (median 39 ml/min) than recipients of younger donor kidneys (median 54 ml/min). However, death-censored graft survival, stratified by eGFR-1, demonstrated similar survival, irrespective of donor age or KDPI. The durability of kidney survival decreases as the achieved eGFR-1 declines. KDPI has a poor association with eGFR-1 and lesser for graft durability. While recipients of kidneys > 65 years had a higher one year mortality than younger kidney recipients, recipients of kidneys > 65 years and an eGFR-1 |
| Databáze: | OpenAIRE |
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