Glucogenesis from sorbitol U-14C in liver slices of starved rats
| Autor: | I.L. MacGregor, E.G. Loten, N. L. Edson |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Male
Biophysics Ketone Bodies In Vitro Techniques Biochemistry Glucose Oxidase chemistry.chemical_compound Residue (chemistry) Polyol Glycerol Animals Sorbitol Moiety Molecular Biology chemistry.chemical_classification Carbon Isotopes Catabolism Rats Glucose Liver chemistry Gluconeogenesis Starvation Glycerophosphates Ketone bodies |
| Zdroj: | Archives of Biochemistry and Biophysics. 116:352-357 |
| ISSN: | 0003-9861 |
| DOI: | 10.1016/0003-9861(66)90041-5 |
| Popis: | The catabolism of sorbitol-U- 14 C has been investigated in liver slices of rats fasted for 24 hours. About 3% of the sorbitol carbon was oxidized to CO 2 and 68% was converted into glucose. The lipid-free residue of the slices contained 14% of the 14 C. About 2% of the 14 C was recovered in the ketone bodies, 0.5% in the triglycerides, and 0.6% in the phospholipids. The free and esterified fatty acids contained little 14 C, but sorbitol carbon was used in the formation of the glycerol moiety. Formation of l -glycerol 1-phosphate from sorbitol may play a part in the antiketogenic action of the polyol. |
| Databáze: | OpenAIRE |
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