Polarized Alloantigen Presentation by Airway Epithelial Cells Contributes to Direct CD8+ T Cell Activation in the Airway
| Autor: | Xue Lin, Daniel Kreisel, J. Lai, Wenjun Li, Alexander S. Krupnick, S.B. Richardson, Aida Ibricevic, Mark J. Miller, Andrew E. Gelman, Ruben G. Nava, C.G. Kornfeld, Steven L. Brody |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Isoantigens T cell Clinical Biochemistry Genes MHC Class I Mice Nude CD8-Positive T-Lymphocytes Lymphocyte Activation Mice Animals Medicine Cytotoxic T cell Lung Molecular Biology Bone Marrow Transplantation Cell Proliferation Cell growth business.industry Epithelial Cells Cell Biology respiratory system Flow Cytometry respiratory tract diseases Mice Inbred C57BL Trachea medicine.anatomical_structure Rapid Communications Mice Inbred CBA Cancer research Respiratory epithelium business Airway CD8 Lung Transplantation Respiratory tract |
| Zdroj: | American Journal of Respiratory Cell and Molecular Biology. 44:749-754 |
| ISSN: | 1535-4989 1044-1549 |
| DOI: | 10.1165/rcmb.2010-0099oc |
| Popis: | Activated T lymphocytes are abundant in the airway during lung allograft rejection. Based on respiratory viral studies, it is the current paradigm that T cells cannot divide in the airway, and that their accumulation in the lumen of the respiratory tract is the exclusive result of recruitment from other sites, such as mediastinal lymph nodes. Here, we show that CD8(+) T cell activation and proliferation can occur in the airway after orthotopic lung transplantation. We also demonstrate that airway epithelium expresses major histocompatibility class I predominantly on the apical surface, both in vitro and in vivo, and initiates CD8(+) T cell responses in a polarized fashion, favoring luminal activation. Our data identify a unique site for CD8(+) T cell activation after lung transplantation, and suggest that attenuating these responses may provide a clinically relevant target. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|