Is a 'watch and wait strategy' safe to manage clinically N0 squamous cell carcinoma of the upper jaw?
| Autor: | Jose Fernadez-Solis, Fernando Monsalve-Iglesias, Ildefonso Martínez-Lara, Almudena Cabello-Serrano, Paolo Cariati |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Palate Hard 0301 basic medicine Cancer Research medicine.medical_specialty medicine.medical_treatment Oral cavity 03 medical and health sciences 0302 clinical medicine medicine Overall survival Humans Basal cell Watchful Waiting Aged Retrospective Studies Nodal involvement Aged 80 and over Maxillary Neoplasms Locoregional failure business.industry Disease Management Neck dissection Middle Aged Prognosis Jaw Neoplasms Surgery Survival Rate stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Neck Dissection T-stage Female Mouth Neoplasms Hard palate Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Current Problems in Cancer. 43:336-343 |
| ISSN: | 0147-0272 |
| DOI: | 10.1016/j.currproblcancer.2018.10.004 |
| Popis: | Purpose: The main aim of the present study is to analyze the behavior of squamous cell carcinoma (SCC) of maxillary gingiva, alveolus, and hard palate and to determine the utility of selective neck dissection in clinically N0 patients at early stages. Material and method Twenty-nine previously untreated patients with SCC of maxillary gingiva, alveolus, and hard palate were diagnosed and treated with at least a tumorectomy and selective neck dissection at HUVN and included in the study. Results A total of 34.4% of patients (10/29) showed nodal involvement at postoperative histopathologic exam. Several pathologic features such as N involvement, N stage, T stage, and locoregional failure all have a negative impact on overall survival. Discussion SCC of maxillary gingiva, alveolus, and hard palate shows an aggressive behavior that is comparable with other oral cavity cancers. A more aggressive treatment is thus required for improving locoregional control and overall survival. Supraomohyoid neck dissection may be useful in cT2N0M0. |
| Databáze: | OpenAIRE |
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