Associations between family history of Parkinson's disease and dementia and risk of dementia in Parkinson's disease: A community-based, longitudinal study
| Autor: | Martin Wilhelm Kurz, Jan Petter Larsen, Dag Aarsland, Jan Terje Kvaløy |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Risk medicine.medical_specialty Longitudinal study Parkinson's disease Time Factors Disease Neuropsychological Tests Central nervous system disease Residence Characteristics Risk Factors mental disorders medicine Dementia Humans Longitudinal Studies Family history Risk factor Age of Onset Psychiatry Aged Proportional Hazards Models Aged 80 and over Family Health Neurologic Examination business.industry Parkinson Disease medicine.disease Neurology Female Neurology (clinical) Age of onset business |
| Zdroj: | Movement disorders : official journal of the Movement Disorder Society. 21(12) |
| ISSN: | 0885-3185 |
| Popis: | Dementia is common in patients with Parkinson's disease (PDD). The etiology of PDD is still unclear, but exciting advances have been made in discovering pathogenetic components in Parkinson's disease (PD), implicating the role of genetic factors. It is, however, still controversial whether genetic factors also contribute to the development of dementia in PD. Thus, we investigated the association between development of dementia and a positive family history of PD or dementia in a community-based study of PD in Rogaland County, Norway (n = 219). The patients were followed prospectively with neurological and neuropsychological assessments. Dementia was more common in patients with a strong family association of PD (first-degree relatives > second-degree relatives > no family history; P < 0.05). However, time to dementia did not differ between the two groups. No associations between dementia in PD and familial occurrence of dementia could be shown. Further studies with larger samples are needed to explore a possible relationship between a family history of PD and development of dementia in PD and its potential pathogenetic mechanisms. |
| Databáze: | OpenAIRE |
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