Preexisting radiological interstitial lung abnormalities are a risk factor for severe radiation pneumonitis in patients with small-cell lung cancer after thoracic radiation therapy

Autor: S. Liang, Ming Chen, Hongyu Wu, Yong Cai, Ailu Wu, F. Li, Ziyang Zhou
Jazyk: angličtina
Rok vydání: 2018
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Male
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
lcsh:R895-920
lcsh:RC254-282
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Honeycombing
Risk factor
Lung cancer
Aged
Aged
80 and over
Lung
Interstitial lung abnormalities-radiation pneumonitis-radiotherapy-small-cell lung cancer
business.industry
Incidence (epidemiology)
Research
Radiotherapy Dosage
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Small Cell Lung Carcinoma
Radiation therapy
Radiation Pneumonitis
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Radiological weapon
Cohort
Female
Radiology
Radiotherapy
Intensity-Modulated
business
Lung Diseases
Interstitial
Tomography
X-Ray Computed
Follow-Up Studies
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 13, Iss 1, Pp 1-9 (2018)
ISSN: 1748-717X
Popis: Background Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT). The present study aimed to evaluate the incidence and predictors of RP after TRT in patients with small-cell lung cancer (SCLC) with or without preexisting radiological ILAs. Methods A total of 95 consecutive patients with SCLC between January 2015 and December 2015, who were treated with thoracic intensity-modulated radiation therapy at Shanghai Pulmonary Hospital,Tongji University School of Medicine, were analyzed. The diagnosis of ILAs was reviewed by two experienced thoracic radiologists based on the pretreatment high-resolution computed tomography imaging, such as honeycombing, subpleural reticular opacities, ground-glass opacity, and traction bronchiectasis. Univariate and multivariate analyses were used to assess the correlation of clinical factors, preexisting radiological ILAs, and dose-volume histogram-based dosimetric parameters with RP. Results Fifteen (15.8%) patients had preexisting radiological ILAs. The incidence of ≥ grade 2 and 3 RP at 1 year was 27.1% and 12.7% in the entire cohort, respectively. Preexisting radiological ILAs were associated with an increased risk of ≥grade 2 RP (50.0% in ILAs + vs 23.3% in ILAs−, P = 0.017) and ≥ grade 3 RP (35.8% in ILAs + vs 8.9% in ILAs−, P = 0.005) at 1 year. Preexisting radiological ILAs and smoking history (≥40 pack-years of smoking) were significant predictors of ≥grade 3 RP in multivariate analysis (P = 0.023 and 0.012, respectively). Conclusions Preexisting radiological ILAs and smoking history (≥40 pack-years of smoking) are associated with an increased risk of ≥grade 3 RP after TRT in patients with SCLC.
Databáze: OpenAIRE
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