Does serum CA-125 level prior to second-look laparotomy for invasive ovarian adenocarcinoma predict size of residual disease?
Autor: | William J. Mann, Bruce Patsner, Edward E. Partridge, James W. Orr, Allmen T, Peyton T. Taylor |
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Rok vydání: | 1990 |
Předmět: |
Reoperation
medicine.medical_specialty medicine.medical_treatment Ovary Disease Adenocarcinoma Residual Gastroenterology Sensitivity and Specificity Predictive Value of Tests Internal medicine Laparotomy Second look laparotomy Biomarkers Tumor Carcinoma medicine Humans Ovarian adenocarcinoma Antigens Tumor-Associated Carbohydrate Neoplasm Invasiveness Prospective Studies Prospective cohort study Cisplatin Ovarian Neoplasms business.industry Obstetrics and Gynecology Combination chemotherapy General Medicine medicine.disease Surgery medicine.anatomical_structure Oncology Predictive value of tests Female Ovarian cancer business medicine.drug Forecasting |
Zdroj: | Gynecologic oncology. 37(3) |
ISSN: | 0090-8258 |
Popis: | The records of 125 patients with nonmucinous invasive ovarian adenocarcinoma who underwent cytoreductive surgery, cisplatin-based combination chemotherapy, and second-look laparotomy were analyzed to correlate pre-second-look serum CA-125 levels with the size of residual ovarian cancer. The majority of patients with negative second-look laparotomy had normal serum CA-125 levels (46/50 or 92%). Of the 75 patients with positive second-look, 56 (75%) had normal CA-125 levels preoperatively. Twenty-three of twenty-four (96%) patients with residual disease less than or equal to 1 cm had normal CA-125 levels as did 20 of 28 (71%) patients with disease 1.1-2.0 cm. Although elevated serum CA-125 levels were invariably associated with visible/gross disease and increasing size of residual disease tended to be associated with increasing elevations of CA-125, normal CA-125 levels often occurred in the presence of large-volume (greater than 2 cm) disease (13/23, 57% of patients). The considerable overlap of serum CA-125 levels for all sizes of residual disease precluded precise prediction of residual disease size based on serum CA-125 level alone. |
Databáze: | OpenAIRE |
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