Anti-inflammatory and antidiabetic effects of grape-derived stilbene concentrate in the experimental metabolic syndrome
| Autor: | Leonid Aliev, Tatiana Pavlovna Makalish, Evgenia Zyablitskaya, Natalia Khimich, Kubyshkin Av, Ivan Fomochkin, Irina Ivanovna Fomochkina, Vitalina Igorevna Petrenko, Leya Evgenievna Sorokina, Alexander Kucherenko, Andrey Ivanovich Gordienko, Alina Alekseevna Shevandova, Natalia Kornienko |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Inflammation 030204 cardiovascular system & hematology Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine Internal Medicine medicine Abdominal obesity biology business.industry Glucose transporter Fructose medicine.disease 030104 developmental biology Endocrinology chemistry biology.protein Metabolic syndrome medicine.symptom business GLUT4 Research Article |
| Zdroj: | J Diabetes Metab Disord |
| ISSN: | 2251-6581 |
| Popis: | AIMS: This study aimed to investigate the carbohydrate and lipid dynamics, associated inflammation markers and the effectiveness of a grape-derived stilbene concentrate (GDSC) treatment in experimental metabolic syndrome (MetS). METHODS: The study was carried out on 40 male 12-weeks of age Wistar rats. The MetS was induced using the fructose model (feeding with 60%-solid fructose diet for 24 weeks). Rats with induced MetS were treated with polyphenolic GDSC, which was obtained by water-alcohol extraction of Vitis vinifera grapevine (Ressfood LLC, Russia). RESULTS: The experimentally induced MetS development leads to classic MetS signs, including abdominal obesity, hyperglycemia, high lipid levels and heart damage. The expression of glucose transporter type 4 (GLUT4) and peroxisome proliferator-activated receptor-γ (PPAR-γ) had greater dynamics than biochemical measurements. The development of the associated inflammatory reactions was confirmed by the increased level of Toll-like receptor type 4 (TLR4) and C-reactive protein (CRP) compared to control levels. The use of the GDSC had positive dynamics in carbohydrate and lipid levels, inflammatory marker, also prevented associated inflammation and heart damage. |
| Databáze: | OpenAIRE |
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