Alpha-1-syntrophin protein is differentially expressed in human cancers
| Autor: | Hina F. Bhat, Rafia A. Baba, Safder Saeed, Firdous A. Khanday, Deeba Kirmani, Mudassir Maqbool Wani, Muneesa Bashir, Khursheed Alam Wani, Nisar A Wani |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Esophageal Neoplasms Health Toxicology and Mutagenesis Clinical Biochemistry Down-Regulation Muscle Proteins Breast Neoplasms Adenocarcinoma medicine.disease_cause Biochemistry Breast cancer Downregulation and upregulation Neoplasms medicine Carcinoma Humans Lung business.industry Stomach Calcium-Binding Proteins Membrane Proteins Middle Aged medicine.disease Up-Regulation medicine.anatomical_structure Carcinoma Squamous Cell Female Breast carcinoma business Carcinogenesis Biomarkers |
| Zdroj: | Biomarkers. 16:31-36 |
| ISSN: | 1366-5804 1354-750X |
| Popis: | We studied the expression of α1-syntrophin (SNTA1) protein in histologically confirmed esophageal, stomach, lung, colon, rectal and breast cancerous tissue samples. Our results suggest a significant decrease in the expression level of SNTA1 protein in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) compared with their respective controls while a significant increase in expression of SNTA1 protein compared with the normal tissue was observed in breast carcinoma samples. No significant difference in expression of SNTA1 protein was observed in stomach, lung, colon and rectal cancers. Our results suggest that SNTA1 has a role in carcinogenesis and could possibly be used as a novel diagnostic or prognostic marker in esophageal and breast cancers. |
| Databáze: | OpenAIRE |
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