Unusual Presentation of Renal Medullary Carcinoma With Undiagnosed Sickle Cell Trait
| Autor: | Jonathan S. England, Giselle Dutcher, Fahmin Basher, Gilberto Lopes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
renal cell carcinoma
Pediatrics medicine.medical_specialty Microcytic anemia 030204 cardiovascular system & hematology Malignancy Renal medullary carcinoma 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal Medicine medicine Hydronephrosis Sickle cell trait business.industry Genitourinary system General Engineering renal medullary carcinoma medicine.disease medicine.anatomical_structure Oncology Nephrology sickle cell trait business Renal pelvis 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Renal medullary carcinoma (RMC) is an extremely rare malignancy that has been described in younger male patients of African descent with a history of sickle cell disease or trait. We describe a rather unique case of RMC in an older male patient who initially presented with acute on chronic urinary retention and concern for infection. Further investigation revealed a history of hematuria and long-standing microcytic anemia, and the patient was found to have sickle cell trait (SCT) as part of a workup for malignancy of unknown primary. Imaging findings initially interpreted as hydronephrosis later characterized a mass in the renal pelvis concerning for a genitourinary malignancy, later biopsy-proven RMC. RMC typically presents in its advanced stages, with associated poor prognosis, and treatment options are limited and have been extrapolated from standard regimens for other genitourinary malignancies. Therefore, early clinical suspicion in patients with microcytic anemia, flank pain, hematuria, and urinary symptoms, can aid in the diagnosis of RMC and allow for prompt intervention. |
| Databáze: | OpenAIRE |
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