Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study
| Autor: | Yajnavalka Banerjee, Ali A. Rizvi, Peter P. Toth, Giuseppe Montalto, Lydia Giannitrapani, Arrigo F G Cicero, Rosaria Vincenza Giglio, Giuseppe Carruba, Manfredi Rizzo, Maciej Banach, Angelo Maria Patti, Maurizio Soresi, Anca Pantea Stoian, Dragana Nikolic, Antonino Terranova |
|---|---|
| Přispěvatelé: | Patti A.M., Carruba G., Cicero A.F.G., Banach M., Nikolic D., Giglio R.V., Terranova A., Soresi M., Giannitrapani L., Montalto G., Stoian A.P., Banerjee Y., Rizvi A.A., Toth P.P., Rizzo M., Patti AM, Carruba G, Cicero AF, Banach M, Nikolic D, Giglio RV, Terranova A, Soresi M, Giannitrapani L, Montalto G, Stoian AP, Banerjee Y, Rizvi AA, Toth PP, Rizzo M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Polyphenol
medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism lcsh:QR1-502 030204 cardiovascular system & hematology Biochemistry Article metabolic syndrome oleocanthal lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Oleocanthal medicine Ingestion 030212 general & internal medicine Molecular Biology Cytokine polyphenols biology business.industry Fatty liver Cytokines metabolic syndrome oleocanthal olive oil polyphenols medicine.disease olive oil cytokines Endocrinology chemistry Alanine transaminase biology.protein Steatosis Metabolic syndrome business Body mass index |
| Zdroj: | Metabolites, Vol 10, Iss 392, p 392 (2020) Metabolites Volume 10 Issue 10 |
| ISSN: | 2218-1989 |
| Popis: | Extra virgin olive oil (EVOO) intake is associated with reduced cardiovascular risk, and its phenolic compound oleocanthal (OC) has anti-oxidant and anti-inflammatory properties. The cardiometabolic effects of EVOO with a high OC concentration have not been fully elucidated. We administered EVOO with a high OC concentration daily to 23 subjects with the metabolic syndrome (MetS) and hepatic steatosis (15 men and 8 women, age: 60 ± 11 years) for 2 months. Anthropometric data, metabolic parameters, hepatic steatosis (by fatty liver index, FLI), abdominal fat distribution (by ultrasound), and pro- and anti-inflammatory cytokines were assessed before and after the intervention. EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-&alpha and IL-1B, while IL-10 increased. Maximum subcutaneous fat thickness (SFT max) also increased, with a concomitant decrease in the ratio of visceral fat layer thickness/SFT max. Correlation analysis revealed positive associations between changes in body weight and BMI and those in SFT max, along with an inverse association between changes in IL-6 and those in SFT max. In conclusion, ingestion of EVOO with a high OC concentration had beneficial effects on metabolic parameters, inflammatory cytokines and abdominal fat distribution in MetS subjects with hepatic steatosis, a category of patients at high cardiometabolic risk. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|