Multiple hypervascular liver nodules in a heavy drinker of alcohol

Autor: Masatoshi Kudo, Ke Ih Kim, Toshihiro Koterazawa, Yoshitake Hayashi, Miyuki Nakaji, Susumu Imoto, Soo Ryang Kim, Kenji Ando, Keiji Mita, Yoshihiko Yano, Toshiyuki Matsuoka, Toshiaki Ninomiya, Katsumi Fukuda, Midori Hirai, Kwansong Ku, Taisuke Nakajima, Yoko Maekawa
Rok vydání: 2005
Předmět:
Zdroj: Journal of Gastroenterology and Hepatology. 20:795-799
ISSN: 1440-1746
0815-9319
DOI: 10.1111/j.1440-1746.2005.03244.x
Popis: A case of hypervascular nodules in the liver, but without hepatitis B or C virus infection in a 38-year-old woman with a history of alcohol abuse is presented. An ultrasound disclosed 1-2-cm hypoechoic tumors in the right and left lobes. Magnetic resonance imaging showed high-intensity tumors at both the T1-weighted and T2-weighted sequences. Incremental dynamic computed tomography and hepatic angiography revealed hypervascular tumors. Ultrasound-guided needle biopsy revealed no evidence of hepatocellular carcinoma, metastatic liver cancer, hemangioendothelioma, inflammatory pseudotumors or pseudolymphoma, but demonstrated stellate-scar fibrosis septa, which contained small unpaired arteries without hyperplasia dividing the nodule. Moreover, marked pericellular fibrosis, neutrophilic infiltration and Mallory bodies were observed in the cytoplasm. There was no evidence of bile duct proliferation. From these findings, the diagnosis of alcohol-induced fibrosis, distinctly different from focal nodular hyperplasia, was tenable. Further studies may provide insights into the pathogenesis of nodule formation and hypervascularity in heavy drinkers of alcohol.
Databáze: OpenAIRE
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