Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial
| Autor: | Ligia de Oliveira Carlos, Marília Rizzon Zaparolli Ramos, Cesar Augusto Taconeli, Alcides José Branco Filho, Magda Rosa Ramos da Cruz, Nathalia Ramori Farinha Wagner, Ingrid Felicidade, Antonio Carlos Ligocki Campos, Ricardo Fernandes |
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| Přispěvatelé: | Universidade Federal do Paraná (UFPR), Federal University of Paraná, Universidade Estadual Paulista (Unesp), Nutrition Course of the Pontifical Catholic University of Paraná (PUCPR), Universidade de São Paulo (USP), Federal University of Grande Dourados, Santa Casa de Misericórdia de Curitiba Hospital, Federal University of Parana |
| Rok vydání: | 2021 |
| Předmět: |
Vitamin
medicine.medical_specialty Roux-en-Y gastric bypass Endocrinology Diabetes and Metabolism Placebo-controlled study 030209 endocrinology & metabolism Placebo Gastroenterology law.invention 03 medical and health sciences chemistry.chemical_compound Probiotic 0302 clinical medicine Lactobacillus acidophilus law Internal medicine medicine Vitamin B12 Glycemic Bariatric surgery Nutrition and Dietetics medicine.diagnostic_test business.industry Probiotics nutritional and metabolic diseases chemistry 030211 gastroenterology & hepatology Surgery Lipid profile business |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | Made available in DSpace on 2021-06-25T10:49:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Abstract: Studies have suggested that Roux-en-Y gastric bypass (RYGB) causes changes in the intestinal microbiota composition and function due to anatomical and physiological modifications. The role of probiotic supplementation after bariatric procedures remains to be determined. Purpose: The aim of this study was to investigate the effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation on nutritional and metabolic parameters after RYGB. Materials and Methods: This is a randomized, double-blind, placebo-controlled clinical trial. Patients were assigned to receive either a probiotic supplement (FloraVantage®) or placebo for three consecutive months, beginning 7 days after surgery. Anthropometric and biochemical indexes were evaluated in the preoperative period and at the end of the study. Results: Following RYGB, serum 25-OH vitamin D increased in both groups compared to baseline; however, this increase was significant only in the probiotic group (p = 0.004). Vitamin B12 levels tended to be higher in the probiotic group compared to the placebo group (p = 0.063), and triglyceride levels showed a significant reduction in the probiotic group only (p < 0.001). In addition, a significant reduction was observed in the anthropometric parameters and glycemic profile (p < 0.05) in both groups. Conclusion: Probiotic supplementation after RYGB improves the vitamin and lipid profile. UFPR Post-graduate Program in Clinical Surgery Surgery Department – Hospital of Clinics Federal University of Paraná, R. Gen. Carneiro, 49 - Alto da Glória, Curitiba -PR School of Medicine Department of Pathology São Paulo State University (UNESP) Nutrition Course of the Pontifical Catholic University of Paraná (PUCPR) Department of Statistics Federal University of Paraná Statistics and Agricultural Experimentation ESALQ-USP Faculty of Health Sciences Federal University of Grande Dourados Santa Casa de Misericórdia de Curitiba Hospital Post-graduate Program in Clinical Surgery Surgery Department Federal University of Parana School of Medicine Department of Pathology São Paulo State University (UNESP) |
| Databáze: | OpenAIRE |
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