Clinicopathologic analysis of intraductal papillary neoplasm of bile duct: Korean multicenter cohort study
| Autor: | Jin Seok Heo, Hongbeom Kim, Heejeong Lee, Jung Hoon Kim, Yoo Seok Yoon, Ho-Seong Han, Sang Jae Park, Il Young Park, Yang Won Nah, Jung Hee Lee, Haeryoung Kim, Joo Young Kim, Hong Jin Kim, Wan-Joon Kim, Eun Kyung Hong, Seung-Mo Hong, Wooil Kwon, Chang Ho Cho, Jae Ri Kim, Hee Sung Kim, Hyung Il Seo, Kyu Yeoun Won, Hye-Jeong Choi, In Woong Han, Young Hun Roh, Kyung-Hee Kim, Jeong Mo Bae, Hyeon Kook Lee, Joon Hyuk Choi, Yu Na Kang, Wonae Lee, Chong Woo Chu, Woo Sung Moon, Kee Taek Jang, In Sang Song, Kyungbun Lee, Young Dong Yu, Sungho Jo, Shin Hwang, Seung Eun Lee, Ho Gak Kim, Hee Chul Yu, Jin Sook Jeong, Jong Sil Lee, Chang-Sup Lim, Sun Whe Kim, Min Sun Cho, Hyung Woo Park, Koo Jeong Kang, Sun Hyung Joo, Do Youn Park, Dong-Sik Kim, Kang Min Han, Jin-Young Jang, Chi Young Jeong, Dong Wook Choi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Gastroenterology Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine Republic of Korea medicine Humans Survival analysis Intraductal Papillary Neoplasm Hepatology Bile duct business.industry Incidence (epidemiology) medicine.disease Bile Ducts Intrahepatic medicine.anatomical_structure Bile Duct Neoplasms Dysplasia 030220 oncology & carcinogenesis Cohort 030211 gastroenterology & hepatology Bile Ducts business Rare disease Cohort study |
| Zdroj: | HPB. 22:1139-1148 |
| ISSN: | 1365-182X |
| DOI: | 10.1016/j.hpb.2019.11.007 |
| Popis: | Background IPNB is very rare disease and most previous studies on IPNB were case series with a small number due to low incidence. The aim of this study is to validate previously known clinicopathologic features of intraductal papillary neoplasm of bile duct (IPNB) based on the first largest multicenter cohort. Methods Among 587 patients previously diagnosed with IPNB and similar diseases from each center in Korea, 387 were included in this study after central pathologic review. We also reviewed all preoperative image data. Results Of 387 patients, 176 (45.5%) had invasive carcinoma and 21 (6.0%) lymph node metastasis. The 5-year overall survival was 80.9% for all patients, 88.8% for IPNB with mucosal dysplasia, and 70.5% for IPNB with invasive carcinoma. According to the “Jang & Kim's modified anatomical classification,” 265 (68.5%) were intrahepatic, 103 (26.6%) extrahepatic, and 16 (4.1%) diffuse type. Multivariate analysis revealed that tumor invasiveness was a unique predictor for survival analysis. (p = 0.047 [hazard ratio = 2.116, 95% confidence interval 1.010–4.433]). Conclusions This is the first Korean multicenter study on IPNB through central pathologic and radiologic review process. Although IPNB showed good long-term prognosis, relatively aggressive features were also found in invasive carcinoma and extrahepatic/diffuse type. |
| Databáze: | OpenAIRE |
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