A large variety of clinical features and concomitant disorders in celiac disease
Autor: | Sebo Withoff, Cisca Wijmenga, Rinse K. Weersma, Ineke L Tan, Marijn C. Visschedijk, Marleen Spijkerman, Jeroen J. Kolkman |
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Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR) |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Pathology Autoimmune diseases PATHOGENESIS Disease Comorbidity Coeliac disease Enteropathy-Associated T-Cell Lymphoma 0302 clinical medicine Microscopic colitis Neoplasms Prevalence Fatigue Netherlands RISK AUTOIMMUNE DISORDERS Gastroenterology Middle Aged Graves Disease Cohort Gastroesophageal Reflux Female 030211 gastroenterology & hepatology Cohort study Adult Diarrhea medicine.medical_specialty Hashimoto Disease DIAGNOSIS Young Adult 03 medical and health sciences Internal medicine Weight Loss medicine Humans Aged Retrospective Studies MALIGNANCY Hepatology business.industry MORTALITY Retrospective cohort study medicine.disease Abdominal Pain Colitis Microscopic Celiac Disease Diabetes Mellitus Type 1 030104 developmental biology Concomitant UPDATE business Constipation |
Zdroj: | Digestive and Liver Disease, 48(5), 499-505. ELSEVIER SCIENCE INC |
ISSN: | 1878-3562 1590-8658 |
Popis: | Background and aims: Celiac disease (CeD) is a gluten triggered, immune-mediated disease of the small intestine. Few clinical cohort descriptions are available, despite the diverse clinical picture. This study provides an overview of a large Dutch CeD cohort focusing on presenting symptoms, co-occurrence of immune mediated diseases (IMD) and malignancies.Methods: We performed a retrospective study in a Dutch university and a non-university medical hospital and included only biopsy proven (>= Marsh type 2 classification) CeD patients.Results: 412 patients were included, selected from 9468 small-bowel biopsy pathology reports and financial codes.Classical symptoms were present in approximately one third of the cohort (diarrhea (37.4%), fatigue (35.0%), weight loss (31.6%), abdominal pain (33.3%)). Atypical symptoms as constipation (10.4%) and reflux (12.4%) were reported as well. 11.7% was diagnosed without reported symptoms.In 25.2% concomitant IMD occurred (most prevalent: type 1 diabetes mellitus (4.9%), microscopic colitis (4.9%), immune mediated-thyroid disease (4.1%)). CeD patients with a concomitant IMD were diagnosed at a significantly higher age compared to those without (P = 0.002). Malignancies occurred in 53 cases (12.9%), including eight Enteropathy Associated T-cell Lymphomas.Conclusion: This is the first study describing a CeD cohort in such detail in the Netherlands and highlights the clinical heterogeneity and importance of screening for concomitant diseases in CeD. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Databáze: | OpenAIRE |
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