A large variety of clinical features and concomitant disorders in celiac disease

Autor: Sebo Withoff, Cisca Wijmenga, Rinse K. Weersma, Ineke L Tan, Marijn C. Visschedijk, Marleen Spijkerman, Jeroen J. Kolkman
Přispěvatelé: Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Molecular Neuroscience and Ageing Research (MOLAR)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Pathology
Autoimmune diseases
PATHOGENESIS
Disease
Comorbidity
Coeliac disease
Enteropathy-Associated T-Cell Lymphoma
0302 clinical medicine
Microscopic colitis
Neoplasms
Prevalence
Fatigue
Netherlands
RISK
AUTOIMMUNE DISORDERS
Gastroenterology
Middle Aged
Graves Disease
Cohort
Gastroesophageal Reflux
Female
030211 gastroenterology & hepatology
Cohort study
Adult
Diarrhea
medicine.medical_specialty
Hashimoto Disease
DIAGNOSIS
Young Adult
03 medical and health sciences
Internal medicine
Weight Loss
medicine
Humans
Aged
Retrospective Studies
MALIGNANCY
Hepatology
business.industry
MORTALITY
Retrospective cohort study
medicine.disease
Abdominal Pain
Colitis
Microscopic
Celiac Disease
Diabetes Mellitus
Type 1
030104 developmental biology
Concomitant
UPDATE
business
Constipation
Zdroj: Digestive and Liver Disease, 48(5), 499-505. ELSEVIER SCIENCE INC
ISSN: 1878-3562
1590-8658
Popis: Background and aims: Celiac disease (CeD) is a gluten triggered, immune-mediated disease of the small intestine. Few clinical cohort descriptions are available, despite the diverse clinical picture. This study provides an overview of a large Dutch CeD cohort focusing on presenting symptoms, co-occurrence of immune mediated diseases (IMD) and malignancies.Methods: We performed a retrospective study in a Dutch university and a non-university medical hospital and included only biopsy proven (>= Marsh type 2 classification) CeD patients.Results: 412 patients were included, selected from 9468 small-bowel biopsy pathology reports and financial codes.Classical symptoms were present in approximately one third of the cohort (diarrhea (37.4%), fatigue (35.0%), weight loss (31.6%), abdominal pain (33.3%)). Atypical symptoms as constipation (10.4%) and reflux (12.4%) were reported as well. 11.7% was diagnosed without reported symptoms.In 25.2% concomitant IMD occurred (most prevalent: type 1 diabetes mellitus (4.9%), microscopic colitis (4.9%), immune mediated-thyroid disease (4.1%)). CeD patients with a concomitant IMD were diagnosed at a significantly higher age compared to those without (P = 0.002). Malignancies occurred in 53 cases (12.9%), including eight Enteropathy Associated T-cell Lymphomas.Conclusion: This is the first study describing a CeD cohort in such detail in the Netherlands and highlights the clinical heterogeneity and importance of screening for concomitant diseases in CeD. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: