Immunological fingerprinting of group B streptococci: from circulating human antibodies to protective antigens
| Autor: | Wolfgang Schüler, Knut Hordnes, Beatrice M. Senn, Dieter Gelbmann, Shailesh Dewasthaly, Eszter Nagy, Birgit Noiges, Markus Hanner, Urban Lundberg, Alexander von Gabain, Jan Sinzinger, Tamás Henics, Helga Masoud, Zehra Visram, Duc Bui Minh, Paul Sevelda, Christina Neubauer, Andreas Meinke |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Virulence Biology Group B Microbiology Streptococcus agalactiae Mice Immune system Antigen Bacterial Proteins Sepsis Streptococcal Infections Animals Humans Antigens Bacterial General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health Immunization Passive Genomics Antibodies Bacterial Vaccination Infectious Diseases Immunization Immunology Mutation biology.protein bacteria Molecular Medicine Female Bacterial antigen Rabbits Antibody Carrier Proteins Gene Deletion |
| Zdroj: | Vaccine. 28(43) |
| ISSN: | 1873-2518 |
| Popis: | Group B streptococcus is one of the most important pathogens in neonates, and causes invasive infections in non-pregnant adults with underlying diseases. Applying a genomic approach that relies on human antibodies we identified antigenic GBS proteins, among them most of the previously published protective antigens. In vitro analyses allowed the selection of conserved candidate antigens that were further evaluated in murine lethal sepsis models using several GBS strains. In active and passive immunization models, we identified four protective GBS antigens, FbsA and BibA, as well as two hypothetical proteins, all shown to contribute to virulence based on gene deletion mutants. These protective antigens have the potential to be components of novel vaccines or targets for passive immune prophylaxis against GBS disease. |
| Databáze: | OpenAIRE |
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