MicroRNA 183 family profiles in pheochromocytomas are related to clinical parameters and SDHB expression

Autor: Victor Liew, Vinod Gopalan, Suja Pillai, Alfred King-Yin Lam, Chung Y. Lo, Minella Lalloz, Robert A. Smith
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Male
endocrine system
Pathology
medicine.medical_specialty
endocrine system diseases
Adolescent
SDHB
Adrenal Gland Neoplasms
Down-Regulation
Pheochromocytoma
Real-Time Polymerase Chain Reaction
Pathology and Forensic Medicine
law.invention
Pathogenesis
03 medical and health sciences
Young Adult
0302 clinical medicine
law
microRNA
medicine
Biomarkers
Tumor
Humans
Prospective Studies
Child
Survival rate
Pathological
Polymerase chain reaction
Aged
business.industry
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Profiling
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Gene Expression Regulation
Neoplastic
Succinate Dehydrogenase
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Child
Preschool
Cancer research
Female
business
Transcriptome
Zdroj: Human pathology. 64
ISSN: 1532-8392
Popis: This study aims to examine the expression profiles of the miR-183 cluster (miR-96/182/183) in pheochromocytoma. Pheochromocytoma tissues were prospectively collected from 50 patients with pheochromocytoma. Expression of miR-183 cluster members and SDHB protein expression were analyzed in these tissues by quantitative real-time polymerase chain reaction and immunohistochemistry, respectively. The expression of miR-183 cluster members in pheochromocytomas was correlated with the clinical and pathological parameters of these patients. The expression levels of miR-183 cluster members were predominantly downregulated or deleted in pheochromocytoma. Low expression or deletion of miR-96 was predominantly noted in younger patients with pheochromocytoma (
Databáze: OpenAIRE
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