Substance P Regulates Puberty Onset and Fertility in the Female Mouse
| Autor: | Andrew Wolfe, John C. Gill, Caroline A Maguire, Ursula B. Kaiser, Víctor M. Navarro, Serap Simavli, Rona S. Carroll, Iain R. Thompson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
puberty 5 aminovalerylsubstance P [7-11][9 proline 10 (n methylleucine)] neurokinin 1 receptor substance P Substance P Stimulation neurokinin 1 receptor agonist Mice chemistry.chemical_compound analogs and derivatives 0302 clinical medicine Endocrinology prepuberty arcuate nucleus Sexual maturity animal genetics nociception Sexual Maturation Receptor Original Research fertility adult Receptors Neurokinin-1 delayed puberty postnatal development metastin female priority journal real time polymerase chain reaction medicine.symptom Gonadotropin hormones hormone substitutes and hormone antagonists Delayed puberty endocrine system medicine.medical_specialty gonadotropin release phenotype regulatory mechanism medicine.drug_class animal experiment Neuropeptide 030209 endocrinology & metabolism Biology Article corpus luteum reverse transcription polymerase chain reaction 03 medical and health sciences follitropin release Internal medicine Tachykinin receptor 1 medicine Animals controlled study gonadotropin mouse nonhuman mediobasal hypothalamus animal model female subfertility Peptide Fragments 030104 developmental biology chemistry gonadorelin peptide fragment drug effects agonists litter size female fertility metabolism Gonadotropins |
| Zdroj: | Endocrinology. 156:2313-2322 |
| ISSN: | 1945-7170 0013-7227 |
| Popis: | Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception, induces gonadotropin release in adult mice in a kisspeptin-dependent manner. Here, we assessed whether SP, through binding to its receptor NK1R (neurokinin 1 receptor), participates in the timing of puberty onset and fertility in the mouse. We observed that 1) selective NK1R agonists induce gonadotropin release in prepubertal females; 2) the expression of Tac1 (encoding SP) and Tacr1 (NK1R) in the arcuate nucleus is maximal before puberty, suggesting increased SP tone; 3) repeated exposure to NK1R agonists prepubertally advances puberty onset; and 4) female Tac1−/− mice display delayed puberty; moreover, 5) SP deficiency leads to subfertility in females, showing fewer corpora lutea and antral follicles and leading to decreased litter size. Thus, our findings support a role for SP in the stimulation of gonadotropins before puberty, acting via Kiss1 neurons to stimulate GnRH release, and its involvement in the attainment of full reproductive capabilities in female mice. |
| Databáze: | OpenAIRE |
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