Characteristics of COPD patients according to GOLD classification and clinical phenotypes in the Russian Federation: the SUPPORT trial
| Autor: | Andrey Lazarev, V. V. Arkhipov, Daria Arkhipova, Marc Miravitlles, Ekaterina Stukalina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Spirometry
Male Chronic bronchitis Pediatrics medicine.medical_specialty Exacerbation spirometry Comorbidity International Journal of Chronic Obstructive Pulmonary Disease Severity of Illness Index Russia 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Russian Federation Adrenal Cortex Hormones Predictive Value of Tests Risk Factors Terminology as Topic Epidemiology medicine COPD Humans 030212 general & internal medicine Diagnostic Errors Lung Original Research Aged medicine.diagnostic_test business.industry phenotypes Reproducibility of Results General Medicine Middle Aged medicine.disease Obstructive lung disease respiratory tract diseases Bronchodilator Agents Cross-Sectional Studies Phenotype Treatment Outcome 030228 respiratory system Disease Progression Russian federation Observational study observational study Female business |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 1176-9106 |
| Popis: | Vladimir Arkhipov,1 Daria Arkhipova,2 Marc Miravitlles,3 Andrey Lazarev,4 Ekaterina Stukalina5 1Clinical Pharmacology and Therapy Department, Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation; 2Clinical Pharmacology and Propaedeutic Internal Diseases Department, First Moscow State Medical University, Moscow, Russian Federation; 3Pneumology Department, Hospital Universitari Vall d’Hebron, Ciber de Enfermedades Respiratorias (CIBERES), Barcelona, Spain; 4AstraZeneca Pharmaceuticals, Moscow, Russian Federation; 5AstraZeneca LP, Gaithersburg, MD, USA Background: The high prevalence of COPD in the Russian Federation has been demonstrated in several epidemiological studies. However, there are still no data on the clinical characteristics of these patients according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups and phenotypes, which could provide additional understanding of the burden of COPD, routine clinical practice, and ways to improve the treatment of patients with COPD in Russia.Patients and methods: SUPPORT was an observational multicenter study designed to obtain data about the distribution of patients with previously diagnosed COPD according to the severity of bronchial obstruction, symptom severity, risk of exacerbation, COPD phenotypes, and treatment of COPD. We included patients with a previous diagnosis of COPD who visited one of 33 primary-care centers for any reason in 23 cities in Russia.Results: Among the 1,505 patients with a previous diagnosis of COPD who attended the primary-care centers and were screened for the study, 1,111 had a spirometry-confirmed diagnosis and were included in the analysis. Up to 53% of the patients had severe or very severe COPD (GOLD stages III–IV), and 74.3% belonged to the GOLD D group. The majority of patients were frequent exacerbators (exacerbators with chronic bronchitis [37.3%], exacerbators without chronic bronchitis [14%]), while 35.8% were nonexacerbators and 12.9% had asthma–COPD overlap. Among the GOLD D group patients, >20% were treated with only short-acting bronchodilators.Conclusion: COPD is still misdiagnosed in primary care in Russia. COPD patients in primary care are usually GOLD D with frequent exacerbations and are often treated with only short-acting bronchodilators. Keywords: COPD, spirometry, observational study, Russian Federation, phenotypes |
| Databáze: | OpenAIRE |
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